Abstract

(A) Animal Models Component? Lung studies The primary goal of the Animal Models component of this program is to coordinate the use of animal models to determine whether nanotechnologies can overcome current important limitations in molecular imaging and gene transfer. Toward this end.
Specific Aims 1 and 2 of the program are directed toward generating and optimizing a panel of single and multi-functional nano structures (e.g., for imaging, tissue targeting, delivery of therapeutics, etc.), while Specific Aims 3 and 4 focus on demonstrating that these nanomaterials are superior to non-nanoparticle alternatives for monitoring gene transcription or for treatment of disease in animal models of both lung and cardiovascular disease that were specifically chosen for these proofof- principle studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL080729-05
Application #
7825443
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
5
Fiscal Year
2009
Total Cost
$317,603
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Fleischmann, Carolin; Anastasaki, Athina; Gutekunst, Will R et al. (2017) Direct Access to Functional (Meth)acrylate Copolymers through Transesterification with Lithium Alkoxides. J Polym Sci A Polym Chem 55:1566-1574
Maji, Dolonchampa; Solomon, Metasebya; Nguyen, Annie et al. (2014) Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography. J Biomed Opt 19:110501
Lundberg, Pontus; Lynd, Nathaniel A; Zhang, Yuning et al. (2013) pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers. Soft Matter 9:82-89
Lee, Annabelle; Lundberg, Pontus; Klinger, Daniel et al. (2013) Physiologically relevant, pH-responsive PEG-based block and statistical copolymers with N,N-diisopropylamine units. Polym Chem 4:5735-5742
Klinger, Daniel; Robb, Maxwell J; Spruell, Jason M et al. (2013) Supramolecular guests in solvent driven block copolymer assembly: From internally structured nanoparticles to micelles. Polym Chem 4:5038-5042
Robb, Maxwell J; Connal, Luke A; Lee, Bongjae F et al. (2012) Functional block copolymer nanoparticles: toward the next generation of delivery vehicles. Polym Chem 3:1618-1628
Amir, Elizabeth; Antoni, Per; Campos, Luis M et al. (2012) Biodegradable, multi-layered coatings for controlled release of small molecules. Chem Commun (Camb) 48:4833-5
Shokeen, Monica; Pressly, Eric D; Hagooly, Aviv et al. (2011) Evaluation of multivalent, functional polymeric nanoparticles for imaging applications. ACS Nano 5:738-47
Sun, Guorong; Cui, Honggang; Lin, Lily Yun et al. (2011) Multicompartment polymer nanostructures with ratiometric dual-emission pH-sensitivity. J Am Chem Soc 133:8534-43
Pressly, Eric D; Amir, Roey J; Hawker, Craig J (2011) Rapid Synthesis of Block and Cyclic Copolymers via Click Chemistry in the Presence of Copper Nanoparticles. J Polym Sci A Polym Chem 49:814-819

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