Abstract

The Clinical Core will be responsible for aiding investigators in carrying out Clinical Proteomic Studies. There will be a Pediatric Section of the Clinical Core and an Adult Section of the Clinical Cere. Dr. Abman will be Director of the Pediatric Section and Dr. Bowler will be director of the Adult Section. Dr. Albert will be a coinvestigator with primary responsibility for COPD and Acute Lung Injury studies. Dr. Kinsella will be a coinvestigator with primary responsibility for BPD studies. Dr. Szefler will be a co-investigator with primary responsibility for Pediatric asthma studies. Dr. Sutherland will be a co-investigator with primary responsibility for Adult asthma studies. Dr. Abraham will be a co-investigator with primary responsibility for Acute Lung Injury studies. Dr. Badesch and Dr. Ivy will be co-investigator in Pulmonary Arterial Hypertension studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL081335-04
Application #
7627295
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$222,511
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Hopper, Rachel K; Abman, Steven H; Ivy, D Dunbar (2016) Persistent Challenges in Pediatric Pulmonary Hypertension. Chest 150:226-36
Laguna, Theresa A; Reilly, Cavan S; Williams, Cynthia B et al. (2015) Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation. Pediatr Pulmonol 50:869-77
Accurso, Frank J; Van Goor, Fredrick; Zha, Jiuhong et al. (2014) Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data. J Cyst Fibros 13:139-47
Wagner, Brandie D; Takatsuki, Shinichi; Accurso, Frank J et al. (2013) Evaluation of circulating proteins and hemodynamics towards predicting mortality in children with pulmonary arterial hypertension. PLoS One 8:e80235
Duncan, Mark; Wagner, Brandie D; Murray, Keri et al. (2012) Circulating cytokines and growth factors in pediatric pulmonary hypertension. Mediators Inflamm 2012:143428
Ratjen, Felix; Saiman, Lisa; Mayer-Hamblett, Nicole et al. (2012) Effect of azithromycin on systemic markers of inflammation in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa. Chest 142:1259-1266
Laguna, Theresa A; Wagner, Brandie D; Starcher, Barry et al. (2012) Urinary desmosine: a biomarker of structural lung injury during CF pulmonary exacerbation. Pediatr Pulmonol 47:856-63
Szefler, Stanley J (2011) Advancing asthma care: the glass is only half full! J Allergy Clin Immunol 128:485-94
Szefler, Stanley J; Dakhama, Azzeddine (2011) New insights into asthma pathogenesis and treatment. Curr Opin Immunol 23:801-7
Cooley, J; Sontag, M K; Accurso, F J et al. (2011) SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition. Eur Respir J 37:1083-90

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