This is a proposal for a three-year renewal of a Cooperative Agreement (UO1) submitted with an Investigator Initiated Project (RO1) on the NIMH Collaborative Program on the Psychobiology of Depression (""""""""the Collaborative Depression Study""""""""). The accompanying RO1 application requests support for the research activities of data collection, processing, editing, and analysis. The purpose of this UO1 application for the Cooperative Agreement is to continue the collaborative effort of a group of senior investigators and the NIMH that has functioned smoothly, efficiently, and productively for over a decade. The Cooperative Agreement application requests support for the maintenance of the infrastructure of communication and administration of the Collaborative Depression Study. This infrastructure will ensure continued scientific integrity of the Collaborative Depression Study, protect its sample and data base, and provide ongoing policy and organization for analysis of data and publication of results. The Cooperative Agreement will provide funds to support the Clinical Studies Committee which is the executive body for the Collaborative Depression Study and is vested with responsibility for all major policy and operational decisions. The Cooperative Agreement will also support the Publication Committee which has authority over presentation and publication of all data emanating from more than one center. This committee reviews proposed analyses, abstracts, manuscripts, etc. to assure adequate sharing of data and quality control. Finally, the Cooperative Agreement will support Cluster Committees, which are organized around functional tasks in substantive areas, and serve to plan and execute important activities of the Collaborative Depression Study. These committees are responsible for making recommendations regarding plans and explication of issues, assessment of alternatives and the conduct of data analyses in each area.
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| Hasin, D S; Tsai, W Y; Endicott, J et al. (1996) Five-year course of major depression: effects of comorbid alcoholism. J Affect Disord 41:63-70 |
| Mannuzza, S; Schneier, F R; Chapman, T F et al. (1995) Generalized social phobia. Reliability and validity. Arch Gen Psychiatry 52:230-7 |
| Reschke, A H; Mannuzza, S; Chapman, T F et al. (1995) Sodium lactate response and familial risk for panic disorder. Am J Psychiatry 152:277-9 |
| Lipsitz, J D; Martin, L Y; Mannuzza, S et al. (1994) Childhood separation anxiety disorder in patients with adult anxiety disorders. Am J Psychiatry 151:927-9 |
| Chapman, T F; Mannuzza, S; Klein, D F et al. (1994) Effects of informant mental disorder on psychiatric family history data. Am J Psychiatry 151:574-9 |
| Chapman, T F; Fyer, A J; Mannuzza, S et al. (1993) A comparison of treated and untreated simple phobia. Am J Psychiatry 150:816-8 |
| Fyer, A J; Mannuzza, S; Chapman, T F et al. (1993) A direct interview family study of social phobia. Arch Gen Psychiatry 50:286-93 |
| Klein, D F; Mannuzza, S; Chapman, T et al. (1992) Child panic revisited. J Am Acad Child Adolesc Psychiatry 31:112-4;discussion 114-6 |
| Mannuzza, S; Fyer, A J; Endicott, J et al. (1992) An extension of the acquaintanceship procedure in family studies of mental disorder. J Psychiatr Res 26:45-57 |
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