The Clinical Studies of the NIMH Collaborative Program on the Psychobiology of depression involves an interrelated and coordinated group of investigations conducted )n two samples drawn from five centers -- mood disordered probands and their relatives. This application seeks to continue the follow up of the samples and to implement several new, but related aims: 1) investigation of the long-term course of illness in probands, relatives, spouses and controls; 2) determination of predictors of onset and recurrence in the same samples; 3) investigation of suicidal behavior. mortality and medical morbidity; 4) investigation of personality disorders in the samples, including validity, joint familial transmission with mood disorders, and influence on clinical course of mood disorders; 5) a genetic linkage study of unipolar and bipolar families; 6) investigation of stability of diagnosis on familial nodes of transmission: 7) further investigation of secular trends in the occurrence of mood disorders.
These aims have important public health, clinical and research implications.
| Neuman, R J; Geller, B; Rice, J P et al. (1997) Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. J Am Acad Child Adolesc Psychiatry 36:466-73 |
| Neuman, R J; Kwon, J M; Jilek-Aall, L et al. (1995) Genetic analysis of kifafa, a complex familial seizure disorder. Am J Hum Genet 57:902-10 |
| Rice, J P; Todorov, A A (1994) Stability of diagnosis: application to phenotype definition. Schizophr Bull 20:185-90 |
| Neuman, R J; Rice, J P (1994) A bit about haplotypes: using binary digits to code tightly linked loci. Hum Hered 44:241-7 |
| Moldin, S O; Rice, J P; Erlenmeyer-Kimling, L et al. (1994) Latent structure of DSM-III-R Axis II psychopathology in a normal sample. J Abnorm Psychol 103:259-66 |
| Moldin, S O; Scheftner, W A; Rice, J P et al. (1993) Association between major depressive disorder and physical illness. Psychol Med 23:755-61 |
| Neuman, R J; Rice, J P; Hampe, C L et al. (1993) Linkage analysis of a complex disease: application to familial Alzheimer's disease. Genet Epidemiol 10:419-24 |
| Rice, J P (1993) Phenotype definition for genetic studies. Eur Arch Psychiatry Clin Neurosci 243:158-63 |
| Neuman, R; Van Eerdewegh, P; Moldin, S et al. (1992) Genetic analysis of cutaneous melanoma and dysplastic nevi under varying phenotypic definitions. Cytogenet Cell Genet 59:214-6 |
| Neuman, R J; Rice, J P (1992) Two-locus models of disease. Genet Epidemiol 9:347-65 |
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