Abstract

The overall objective of this ICBG is to stimulate biodiversity conservation in Suriname by demonstrating the value of biodiversity to Suriname and the Surinamese people. This will be done both by developing potential medicinal agents from Surinamese flora and by a program of educational and extension activities in Suriname. License fees and royalties from compounds selected for development will be returned in part to Suriname for distribution to the Surinamese people. Plants will be collected in Suriname by the Missouri Botanical Garden, working in collaboration with the National Herbarium of Suriname. Ethnobotanical, conservation, educational, and extension activities will be carried out by Conservation International, in collaboration with Conservation International-Suriname. Collected plants will be extracted by Bedriff Geneesmiddelen Voorziening Suriname (BGVS), and extracts will be shipped to Bristol-Myers Squibb Research Institute (BMS) for bioassay. Active extracts will then be fractionated at BGVS, BMS, or at Virginia Polytechnic Institute and State University, depending on the nature of the bioactivity. Active compounds will be patented and then subjected to further biological testing at BMS. Those selected for development will be licensed to BMS, with a pre-arranged division of fees and royalties between the inventors and Suriname.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01TW000313-02
Application #
2291797
Study Section
Special Emphasis Panel (SRC (05))
Project Start
1993-09-30
Project End
1998-09-29
Budget Start
1994-09-30
Budget End
1995-09-29
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Virginia Polytechnic Institute and State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24061

  Publications

Du, Yongle; Abedi, Alexander K; Valenciano, Ana Lisa et al. (2017) Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp. (Meliaceae) from Madagascar. Chem Biodivers 14:
Presley, Christopher C; Du, Yongle; Dalal, Seema et al. (2017) Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium. Bioorg Med Chem 25:4203-4211
Applequist, Wendy L; Ratsimbason, Michel; Kuhlman, Alyse et al. (2017) Antimalarial Use of Malagasy Plants is Poorly Correlated with Performance in Antimalarial Bioassays. Econ Bot 71:75-82
Rasamison, Vincent E; Brodie, Peggy J; Merino, Emilio F et al. (2016) Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis (Baker) T.G. Hartley. Nat Prod Bioprospect 6:261-265
Su, Qingxi; Brodie, Peggy J; Liu, Yixi et al. (2016) Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest. Nat Prod Bioprospect 6:31-9
Liu, Yixi; Wiedle Jr, C Houston; Brodie, Peggy J et al. (2015) Antiproliferative Diterpenes from a Malleastrum sp. from the Madagascar dry forest. Nat Prod Commun 10:1509-12
Bao, Xingfeng; Zheng, Wanjun; Hata Sugi, Naoko et al. (2015) Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking. Cancer Biol Ther 16:589-601
Liu, Yixi; Cheng, Emily; Rakotondraibe, L Harinantenaina et al. (2015) Antiproliferative Compounds from Ocotea macrocarpa from the Madagascar Dry Forest(1). Tetrahedron Lett 56:3630-3632
Presley, Christopher C; Rakotondraibe, L Harinantenaina; Brodie, Peggy J et al. (2015) A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest. Nat Prod Commun 10:1505-7
Liu, Yixi; Rakotondraibe, L Harinantenaina; Brodie, Peggy J et al. (2015) Antimalarial 5,6-Dihydro-?-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-?-Pyrones Are Artifacts1. J Nat Prod 78:1330-8

Showing the most recent 10 out of 104 publications