Abstract

The purpose of this project is to continue and expand the active participation of Harbor General Hospital and affiliated institutions in all phases of the Children's Cancer Study Group. The research involves a multi-disciplinarian approach to the clinical investigation of childhood cancer with special emphasis on chemotherapy of Acute Leukemia and Solid Tumors of Childhood with collaborative protocols developed by the Children's Cancer Study Group. We will continue in the study and the treatment of pediatric oncologic disorders by means of Phase I, II, and III Protocols. In addition, pertinent questions regarding natural history, treatment and epidemiology of childhood cancer will be investigated. APPROACH: The results of therapies are recorded by the institutions' pediatric oncology staff, including Data Managers, and Protocol Nurse Coordinators, supervised by Sub-specialists in Pediatric Oncology. Information is forwarded to the Operations Office for detailed statistical analysis. The ultimate benefit is that the investigation involves controlled clinical trials in leukemia and solid tumors of childhood, controlled evaluations of newly developed therapeutic agents and controlled studies of the effects of immunotherapy and immuno-suppression. Children participating in this project will benefit by being offered the most up-to-date methods of diagnosis, treatment and management of their disorders. The program seeks a scientific approach to a comprehensive, therapeutic investigation of childhood cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA014560-14
Application #
3556267
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1976-12-01
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
14
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Los Angeles County Harbor-UCLA Medical Center
Department
Type
DUNS #
City
Torrance
State
CA
Country
United States
Zip Code
90509

  Publications

Seitzman, Robin L; Glover, Dorie A; Meadows, Anna T et al. (2004) Self-concept in adult survivors of childhood acute lymphoblastic leukemia: a cooperative Children's Cancer Group and National Institutes of Health study. Pediatr Blood Cancer 42:230-40
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Davies, Stella M; Bhatia, Smita; Ross, Julie A et al. (2002) Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood 100:67-71
Wells, Robert J; Reid, Joel M; Ames, Matthew M et al. (2002) Phase I trial of cisplatin and topotecan in children with recurrent solid tumors: Children's Cancer Group Study 0942. J Pediatr Hematol Oncol 24:89-93
Lange, Beverly J; Bostrom, Bruce C; Cherlow, Joel M et al. (2002) Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood 99:825-33
Ou, Shu Xiao; Han, Dehui; Severson, Richard K et al. (2002) Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). Cancer Causes Control 13:15-25
Cairo, M S; Krailo, M D; Morse, M et al. (2002) Long-term follow-up of short intensive multiagent chemotherapy without high-dose methotrexate ('Orange') in children with advanced non-lymphoblastic non-Hodgkin's lymphoma: a children's cancer group report. Leukemia 16:594-600
Wells, R J; Arthur, D C; Srivastava, A et al. (2002) Prognostic variables in newly diagnosed children and adolescents with acute myeloid leukemia: Children's Cancer Group Study 213. Leukemia 16:601-7
Meyers, P A; Krailo, M D; Ladanyi, M et al. (2001) High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. J Clin Oncol 19:2812-20
Sposto, R; Meadows, A T; Chilcote, R R et al. (2001) Comparison of long-term outcome of children and adolescents with disseminated non-lymphoblastic non-Hodgkin lymphoma treated with COMP or daunomycin-COMP: A report from the Children's Cancer Group. Med Pediatr Oncol 37:432-41

Showing the most recent 10 out of 14 publications