As a participting institution in the Primary Breast Cancer Therapy Group (NSABP) we are contributing data from patients entered into the various group protocols. Patients have been entered into Protocol 5, which compared L-PAM with L-PAM and 5-FU, and Protocol 8, which compared the worth of 3 drug chemotherapy (L-PAM, 5-FU, and MTX) with a 2 drug chemotherapy (L-PAM and 5-FU). Protocol No. 6: A trial to compare the worth of segmental mastectomy with and without breast radiation with total mastectomy plus axillary dissection. All patients will undergo axillary dissection and those with histologically positive axillary nodes will receive adjuvant chemotherapy. Protocol No. 9: A trial to determine whether the anti-estrogen Tamoxifen when combined with chemotherapy improves the results obtained with chemotherapy alone. In addition, the NSABP has implemented adjuvant protocols for primary colon and rectal carcinoma. The present application seeks funding (a) to permit continued patient accrual in on-going protocols, (b) to continue follow-up of patients entered into protocols which have terminated, and (c) to collect appropriate biological material and information relevant to such protocols. Finally, the aim of this proposal is to enhance the multidisciplinary approach of this institution in these clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA020187-15
Application #
3556467
Study Section
Special Emphasis Panel (SRC (27))
Project Start
1977-02-01
Project End
1992-01-31
Budget Start
1991-02-01
Budget End
1992-01-31
Support Year
15
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Pennsylvania Hospital (Philadelphia)
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19107