Abstract

The Pediatric Hemotology Oncology Division at Emory University is the only pediatric cancer center within a radius of 180 miles. This center offers multimodal therapy to children with malignant diseases. The pediatric division of Emory University is the largest single contributor of patients to the Pediatric Oncology Group. This division is unique in that it cares for private patients at Emory University Clinic and Egleston Hospital and for indigent patients at Grady Memorial Hospital. This division cares for children in the Atlanta area (population 1.9 million), the State of Georgia and other neighboring states including North and South Carolina and Alabama. Several basic research projects are currently underway at Emory University. These include the investigation of granulopoiesis in children with acute non-lymphocytic leukemia. Bone marrow cells from children with acute non-lymphocytic leukemia are shipped from all institutions in the Pediatric Oncology Group. The bone marrow cells are cultured in agar to assess if the growth pattern of these cells is of prognostic value. In addition, we have established 3 cell lines from children with acute leukemia--one T cell and two transitional B cell lines. These cell lines are being utilized to test the effect of various chemotherapy agents on them. In addition, we are successfully culturing tumor cells in agar cultures. These studies may help in the treatment in children with malignant disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA020549-09
Application #
3556535
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-01-01
Project End
1986-01-31
Budget Start
1985-01-01
Budget End
1986-01-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Adamkiewicz, T V; Mehta, P S; Boyer, M W et al. (2004) Transplantation of unrelated placental blood cells in children with high-risk sickle cell disease. Bone Marrow Transplant 34:405-11
Seitzman, Robin L; Glover, Dorie A; Meadows, Anna T et al. (2004) Self-concept in adult survivors of childhood acute lymphoblastic leukemia: a cooperative Children's Cancer Group and National Institutes of Health study. Pediatr Blood Cancer 42:230-40
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Goorin, Allen M; Schwartzentruber, Douglas J; Devidas, Meenakshi et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574-80
Laver, Joseph H; Mahmoud, Hazem; Pick, Terry E et al. (2002) Results of a randomized phase III trial in children and adolescents with advanced stage diffuse large cell non-Hodgkin's lymphoma: a Pediatric Oncology Group study. Leuk Lymphoma 43:105-9
Lauer, S J; Shuster, J J; Mahoney Jr, D H et al. (2001) A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial. Leukemia 15:1038-45
Saylors 3rd, R L; Stine, K C; Sullivan, J et al. (2001) Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study. J Clin Oncol 19:3463-9
Hu, J; Schuster, A E; Fritsch, M K et al. (2001) Deletion mapping of 6q21-26 and frequency of 1p36 deletion in childhood endodermal sinus tumors by microsatellite analysis. Oncogene 20:8042-4

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