The North Central Cancer Treatment Group (NCCTG) is a multidisciplinary clinical trials organization which is comprised primarily of community clinics. The NCCTG is affiliated with the NCI-designated Mayo Clinic Cancer Center as its research base. The primary cancer treatment objective of the NCCTG is to improve survival and quality of life for patients with malignant disease by conducting high quality cancer treatment research studies based upon sound scientific hypotheses. Our organization is devoted to the care of cancer patients, and is based on the premises that quality cancer treatment research can be conducted by the community clinic, and that the community clinic provides the ultimate proving ground for applicability of new cancer treatment procedures to the general population.
Our specific aims during the next grant period are to: (1) provide an infrastructure to facilitate high quality translational research in collaborative with laboratory scientists at the Mayo Cancer Center and other research organizations: (2) provide cancer patients access to the highest quality of oncologic care in a research setting in or near their home community; (3) facilitate communication between the community clinics, research base, other cooperative groups and the National Cancer Institute with respect to clinical cancer research. (4) provide underserved populations access to NCCTG clinical research protocols. We intend to achieve these goals through close coordination of the NCCTG research agenda with that of the Mayo Clinic Cancer Center to take advantage of the considerable strengths of these two distinct research programs in order to achieve common objective in an efficient and cost- effective manner.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA025224-21
Application #
6137382
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Program Officer
Mooney, Margaret M
Project Start
1982-01-01
Project End
2000-12-31
Budget Start
2000-01-28
Budget End
2000-12-31
Support Year
21
Fiscal Year
2000
Total Cost
$4,369,642
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Chumsri, Saranya; Sperinde, Jeff; Liu, Heshan et al. (2018) High p95HER2/HER2 Ratio Associated With Poor Outcome in Trastuzumab-Treated HER2-Positive Metastatic Breast Cancer NCCTG N0337 and NCCTG 98-32-52 (Alliance). Clin Cancer Res 24:3053-3058
Barton, Debra L; Sloan, Jeff A; Shuster, Lynne T et al. (2018) Evaluating the efficacy of vaginal dehydroepiandosterone for vaginal symptoms in postmenopausal cancer survivors: NCCTG N10C1 (Alliance). Support Care Cancer 26:643-650
McCleary, Nadine J; Hubbard, Joleen; Mahoney, Michelle R et al. (2018) Challenges of conducting a prospective clinical trial for older patients: Lessons learned from NCCTG N0949 (alliance). J Geriatr Oncol 9:24-31
Feliciano, Josephine L; Le-Rademacher, Jennifer G; Gajra, Ajeet et al. (2018) Do older patients with non-small cell lung cancer also benefit from first-line platinum-based doublet chemotherapy? Observations from a pooled analysis of 730 prospectively-treated patients (Alliance Study A151622). J Geriatr Oncol 9:501-506
Schiff, David; Jaeckle, Kurt A; Anderson, S Keith et al. (2018) Phase 1/2 trial of temsirolimus and sorafenib in the treatment of patients with recurrent glioblastoma: North Central Cancer Treatment Group Study/Alliance N0572. Cancer 124:1455-1463
McWilliams, Robert R; Allred, Jacob B; Slostad, Jessica A et al. (2018) NCCTG N0879 (Alliance): A randomized phase 2 cooperative group trial of carboplatin, paclitaxel, and bevacizumab?±?everolimus for metastatic melanoma. Cancer 124:537-545
Churilla, Thomas M; Ballman, Karla V; Brown, Paul D et al. (2017) Stereotactic Radiosurgery With or Without Whole-Brain Radiation Therapy for Limited Brain Metastases: A Secondary Analysis of the North Central Cancer Treatment Group N0574 (Alliance) Randomized Controlled Trial. Int J Radiat Oncol Biol Phys 99:1173-1178
Jansson-Knodell, Claire L; Foster, Nathan R; Sargent, Daniel J et al. (2017) Family history of colorectal cancer and its impact on survival in patients with resected stage III colon cancer: results from NCCTG Trial N0147 (Alliance). J Gastrointest Oncol 8:1-11
Mehrotra, Shailly; Sharma, Manish R; Gray, Elizabeth et al. (2017) Kinetic-Pharmacodynamic Model of Chemotherapy-Induced Peripheral Neuropathy in Patients with Metastatic Breast Cancer Treated with Paclitaxel, Nab-Paclitaxel, or Ixabepilone: CALGB 40502 (Alliance). AAPS J 19:1411-1423
Sonnenblick, Amir; Agbor-Tarh, Dominique; Bradbury, Ian et al. (2017) Impact of Diabetes, Insulin, and Metformin Use on the Outcome of Patients With Human Epidermal Growth Factor Receptor 2-Positive Primary Breast Cancer: Analysis From the ALTTO Phase III Randomized Trial. J Clin Oncol 35:1421-1429

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