Clinical and laboratory research studies are continuing at the University of Alabama at Birmingham in collaboration with the Pediatric Oncology Group (POG). Participation in phase III therapeutic trials employing multi-modality treatment (surgery, chemotherapy and radiotherapy) for children with a variety of hematopoietic malignancies and solid tumors continues. Summaries of current results of these trials are in some cases already published, and a compilation of pertinent publications from these cooperative group efforts can be obtained from the POG Operations office. We also participate in pilot studies for new regimens and investigations of new chemotherapy agents through phase II trials. The University of Alabama at Birmingham will be providing the reference lab facilities for the cytogenetic investigative activities for POG. Specifically, bone marrow and in some instances peripheral blood samples from patients with lymphoid and myeloid leukemias will be shipped to Birmingham for banded chromosome analysis as required by the various hematopoietic malignancy protocols. Data will be compiled and sent back to the specific coordinator for final evaluation. By standardizing these methods, the resultant data will be more reliable and consistent. We are maintaining a centralized sera and plasma repository with clinical and demographic data referenced on computer. These patient materials have been used in studies of HLA and Bf, C4 typing studies and will be used by POG investigators for future basic science studies. UAB investigators are also coordinating clinical trials for the evaluation of treatment methods in children with neuroblastoma, assessment of aziridinylbenzoquinone in children with recurrent brain and other solid tumors, and establishing treatment methods for children with ependymomas of various grades. We are instituting studies on a Group wide basis for investigating the psychosocial implications of childhood cancer in patients and their families.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA025408-11
Application #
3556750
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1979-03-01
Project End
1990-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Henderson, Tara O; Bhatia, Smita; Pinto, Navin et al. (2011) Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children's Oncology Group study. J Clin Oncol 29:76-82
Schneiderman, Jennifer; London, Wendy B; Brodeur, Garrett M et al. (2008) Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. J Clin Oncol 26:913-8
Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Moreau, Lisa A; McGrady, Patrick; London, Wendy B et al. (2006) Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study. Clin Cancer Res 12:5693-7
Whitehead, V M; Shuster, J J; Vuchich, M J et al. (2005) Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 19:533-6
George, Rani E; London, Wendy B; Cohn, Susan L et al. (2005) Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol 23:6466-73
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Maris, John M; Castleberry, Robert P (2003) Chemotherapy for neuroblastoma: is it all or none? J Pediatr Hematol Oncol 25:512-4
Goorin, Allen M; Schwartzentruber, Douglas J; Devidas, Meenakshi et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574-80

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