This proposal represents a request to support continued participation in the Pediatric Oncology Group (POG). This cooperative research is devoted to the investigation of chemotherapeutic and other new innovative approaches to the treatment of acute leukemia and other neoplastic diseases of childhood. Significant palliation and prolongation of survival has been achieved and contributions have been made in clinical pharmacology. However, the real objective of these studies is the eradication of neoplastic diseases by treatment. Studies are being designed to reflect an increasing intensity of attack on the neoplastic cell. The cooperative group technique permits prompt evaluation in series of reasonable size of promising leads in chemotherapy. These leads or new approaches are often suggested by the results of the group's own work in clinical oncology. Thus, a completed protocol often suggests new avenues to be explored in new protocols. POG also led in the investigation of immunophenotyping of acute lymphoblastic leukemia, correlating it with prognosis and designing appropriate treatment protocols accordingly. The Division of Pediatric Hematology/Oncology in the Department of Pediatrics at the University of California, San Diego had a 10 year involvement in cooperative group studies with Cancer and Leukemia Group B prior to joining forces with POG in 1980. We have been one of the major contributors in patient registry to group protocol studies. In the last 4 years (Nov. 1984 - Nov. 1988), we have entered 457 patients on Group protocol studies. For the year from May 1988 through May 1989, there were 110 patients entered from UCSD. Both Drs. Faith Kung and Alice Yu chair group therapeutic protocols (-leukemia, Hodgkin's disease and new agents). Dr. Yu's laboratory also serves as the group reference laboratory for the study of the pharmacology of deoxycoformycin GD2, a tumor marker for neuroblastoma. Dr. Wayne Spruce is actively involved with group protocols on bone marrow transplantation. Dr. Hector James serves on the Brain Tumor Committee. Dr. William Thomas is a study coordinator for the protocol on the treatment of germ cell tumors. Dr. John Fontanesi is the driving force behind the design of neuropsychological testing for group protocol studies on low rade cerebellar astrocytomas and visual pathway tumors. We plan to continue our active participation in all phases of POG activities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA028439-15
Application #
2087733
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1980-07-01
Project End
1995-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
15
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wacker, Pierre; Land, Vita J; Camitta, Bruce M et al. (2007) Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 29:627-32
Kung, Faith H; Schwartz, Cindy L; Ferree, Carolyn R et al. (2006) POG 8625: a randomized trial comparing chemotherapy with chemoradiotherapy for children and adolescents with Stages I, IIA, IIIA1 Hodgkin Disease: a report from the Children's Oncology Group. J Pediatr Hematol Oncol 28:362-8
Ravindranath, Y; Chang, M; Steuber, C P et al. (2005) Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-16
Shamberger, Robert C; LaQuaglia, Michael P; Gebhardt, Mark C et al. (2003) Ewing sarcoma/primitive neuroectodermal tumor of the chest wall: impact of initial versus delayed resection on tumor margins, survival, and use of radiation therapy. Ann Surg 238:563-7; discussion 567-8
Goorin, Allen M; Schwartzentruber, Douglas J; Devidas, Meenakshi et al. (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574-80
Lacayo, N J; Lum, B L; Becton, D L et al. (2002) Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia. Leukemia 16:920-7
Omura-Minamisawa, M; Diccianni, M B; Batova, A et al. (2000) In vitro sensitivity of T-cell lymphoblastic leukemia to UCN-01 (7-hydroxystaurosporine) is dependent on p16 protein status: a Pediatric Oncology Group study. Cancer Res 60:6573-6
Mahoney Jr, D H; Cohen, M E; Friedman, H S et al. (2000) Carboplatin is effective therapy for young children with progressive optic pathway tumors: a Pediatric Oncology Group phase II study. Neuro Oncol 2:213-20
Abshire, T C; Pollock, B H; Billett, A L et al. (2000) Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood 96:1709-15
Kung, F H; Harris, M B; Krischer, J P (1999) Ifosfamide/carboplatin/etoposide (ICE), an effective salvaging therapy for recurrent malignant non-Hodgkin lymphoma of childhood: a Pediatric Oncology Group phase II study. Med Pediatr Oncol 32:225-6

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