This application is submitted by the Cancer And Leukemia Group B (CALGB) to begin its sixteenth year as a primary multi-modality Research Base for seven Community Clinical Oncology Programs (CCOPs) and two Minority-Based CCOPs. CALGB is a Clinical Cooperative Group with 30 Main Member institutions and a membership of about 3000 health professionals at about 200 hospitals, clinics and physicians' offices. The overall objective is to provide an organized and collegial environment for community based health care professionals to interact with their academic counter-parts in the development and implementation of cancer prevention and control research studies and the latest cancer treatment clinical trials. CALGB proposes to enhance the translation of new information from a strong basic correlative sciences program in cancer treatment to an evolving strong program in cancer prevention and control research. Major themes are chemoprevention, intermediate markers and quality of life research. Strategies will be developed to assist CCOPs to increase accrual of minorities, women and other underserved people into ethical, high quality clinical trials which will result in a decrease in cancer incidence, morbidity and mortality. A special focus has emerged in cancer in the elderly and a new committee is charged with developing research studies of particular relevance to this rapidly growing segment of the population. CCOPs will be assisted in broadening their networks to include more primary health professionals and specialists to help in the diffusion of state-of-the-art cancer care at the community level. There are seven cancer site committees (Breast, Gastrointestinal, Leukemia, Lymphoma, Melanoma, Prostate and Respiratory) which work closely with thirteen modality committees (Pharmacology and Experimental Therapeutics, Correlative Sciences- Leukemia/Lymphoma, Correlative Sciences-Solid Tumors, Transplant, Pathology, Surgery, Radiation Oncology, Psycho-Oncology, Cancer Control, Oncology Nursing, Patient Issues, Clinical Research Associates, Cancer in the Elderly) to plan and implement cancer prevention and treatment studies using the latest technologies and information available. This project will bring these advances to the community hospital level where CCOP trained health care providers can apply them immediately.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10CA037447-16
Application #
2867953
Study Section
Special Emphasis Panel (ZCA1-SRRB-7 (J4))
Project Start
1983-09-30
Project End
2004-05-31
Budget Start
1999-08-27
Budget End
2000-05-31
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Orchard, Tonya S; Andridge, Rebecca R; Yee, Lisa D et al. (2018) Diet Quality, Inflammation, and Quality of Life in Breast Cancer Survivors: A Cross-Sectional Analysis of Pilot Study Data. J Acad Nutr Diet 118:578-588.e1
Parsons, J Kellogg; Pierce, John P; Mohler, James et al. (2018) Men's Eating and Living (MEAL) study (CALGB 70807 [Alliance]): recruitment feasibility and baseline demographics of a randomized trial of diet in men on active surveillance for prostate cancer. BJU Int 121:534-539
Mandelblatt, Jeanne S; Cai, Ling; Luta, George et al. (2017) Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance). Breast Cancer Res Treat 164:107-117
Himelstein, Andrew L; Foster, Jared C; Khatcheressian, James L et al. (2017) Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial. JAMA 317:48-58
Holstein, Sarah A; Jung, Sin-Ho; Richardson, Paul G et al. (2017) Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial. Lancet Haematol 4:e431-e442
Basch, Ethan; Dueck, Amylou C; Rogak, Lauren J et al. (2017) Feasibility Assessment of Patient Reporting of Symptomatic Adverse Events in Multicenter Cancer Clinical Trials. JAMA Oncol 3:1043-1050
Hacker, Eileen Danaher; Kim, Inah; Park, Chang et al. (2017) Real-time Fatigue and Free-Living Physical Activity in Hematopoietic Stem Cell Transplantation Cancer Survivors and Healthy Controls: A Preliminary Examination of the Temporal, Dynamic Relationship. Cancer Nurs 40:259-268
Hacker, Eileen Danaher; Fink, Anne M; Peters, Tara et al. (2017) Persistent Fatigue in Hematopoietic Stem Cell Transplantation Survivors. Cancer Nurs 40:174-183
Ji, YongLi; Rounds, Tiffany; Crocker, Abigail et al. (2016) The Effect of Atorvastatin on Breast Cancer Biomarkers in High-Risk Women. Cancer Prev Res (Phila) 9:379-84
Zimmerman, Collin; Atherton, Pamela J; Pachman, Deirdre et al. (2016) MC11C4: a pilot randomized, placebo-controlled, double-blind study of venlafaxine to prevent oxaliplatin-induced neuropathy. Support Care Cancer 24:1071-8

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