The University of Iowa has been a member of CALGB since 1986. Accrual at the main member hospital is approximately 100 patients per year and approximately 20 more patients are accrued at two affiliates. Over the past 5 years, we have authored or co-chaired studies in non-small cell lung cancer, in chemoprevention of lung cancer, in experimental therapeutics for 506U78, and for omega-3 fatty acids in cancer cachexia. Administratively, Dr. Gerald Clamon has been vice chair of the Membership Committee and Dr. Raymond Hohl has been vice chair of the Institutional Performance Evaluation Committee (IPEC). In addition, Dr. Clamon is on the Respiratory Committee and is the liaison to the Cancer Control and Health Outcomes Committee, Dr. Hohl is on the Leukemia Committee and is the liaison to the Pharmacology and Experimental Therapeutics (PET) Committee, Dr. Brian Link is on the Lymphoma Committee, and Dr. Badrinath Konety is on the GU Committee. Dr. Nancy Rosenthal is reviewing slides for the Hematopathology Committee for a lymphoma trial, Dr. Shivanand Patel reviews cytogenetics for the Leukemia Committee, and Dr. Michael Vannier is serving on a new committee to evaluate new technologies in the imaging of tumors. New translational research at the University of Iowa has lead to the development of two new promising anti-cancer therapies. The HU 1D10 antibody developed in the laboratory of Dr. George Weiner at the University of Iowa has completed Phase I trials at the University of Iowa and demonstrated activity against lymphoma. The CpG oligodeoxynucleotide developed at the University of Iowa in the lab or Dr. Arthur Krieg is now completing Phase I trials at the University of Iowa. A pilot study of Pneumovax plus GM-CSF is being completed at the University of Iowa. This should lead to a phase III trial within CALGB and potentially improve success with vaccinations of the immune suppressed cancer patient. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA047642-17
Application #
6743671
Study Section
Subcommittee G - Education (NCI)
Program Officer
Mooney, Margaret M
Project Start
1988-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
17
Fiscal Year
2004
Total Cost
$153,215
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
D'Angelo, Sandra P; Mahoney, Michelle R; Van Tine, Brian A et al. (2018) Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials. Lancet Oncol 19:416-426
Basch, Ethan; Dueck, Amylou C; Rogak, Lauren J et al. (2017) Feasibility Assessment of Patient Reporting of Symptomatic Adverse Events in Multicenter Cancer Clinical Trials. JAMA Oncol 3:1043-1050
Fuchs, Charles S; Niedzwiecki, Donna; Mamon, Harvey J et al. (2017) Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance). J Clin Oncol 35:3671-3677
Martin, Linda W; D'Cunha, Jonathan; Wang, Xiaofei et al. (2016) Detection of Occult Micrometastases in Patients With Clinical Stage I Non-Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance). J Clin Oncol 34:1484-91
Morrison, Vicki A; Jung, Sin-Ho; Johnson, Jeffrey et al. (2015) Therapy with bortezomib plus lenalidomide for relapsed/refractory mantle cell lymphoma: final results of a phase II trial (CALGB 50501). Leuk Lymphoma 56:958-64
Rugo, Hope S; Barry, William T; Moreno-Aspitia, Alvaro et al. (2015) Randomized Phase III Trial of Paclitaxel Once Per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once Per Week or Ixabepilone With Bevacizumab As First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: CALGB 40502/NCCTG N0 J Clin Oncol 33:2361-9
Du, Juan; Lopez-Verges, Sandra; Pitcher, Brandelyn N et al. (2014) CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. Cancer Immunol Res 2:878-89
Heist, Rebecca S; Wang, Xiaofei; Hodgson, Lydia et al. (2014) CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer. J Thorac Oncol 9:214-21
Wang, Xiaofeng; Owzar, Kouros; Gupta, Pankaj et al. (2014) Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome: CALGB 10105 (Alliance). Br J Clin Pharmacol 78:1005-13
Rizzieri, David A; Johnson, Jeffrey L; Byrd, John C et al. (2014) Improved efficacy using rituximab and brief duration, high intensity chemotherapy with filgrastim support for Burkitt or aggressive lymphomas: cancer and Leukemia Group B study 10 002. Br J Haematol 165:102-11

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