The University of Pretoria, a member of ECOG since 1972, is requesting support to facilitate continued participation in ECOG. As a member of ECOG, this institution is attempting to improve both the quality and duration of cancer patients' lives by developing and scientifically evaluating the most effective treatment programs for all types and stages of cancer.
The specific aims of this program are: (1) to maintain a high accrual rate of fully evaluable patients on all ECOG therapeutic and non-therapeutic protocols; (2) to maintain and refine an effective data management program; (3) to continue contribution to the development of innovative treatment protocols and continue leadership in the scientific programs of ECOG; (4) to publish results of ECOG studies; (5) to continue to present the scientific information gathered by ECOG at national and international meetings; and (6) to contribute to ECOG and NCI programs on hepatocellular carcinoma, esophagus cancer, and mesothelioma where this institution has unique resources. Investigators from the University of Pretoria chair or have chaired several ECOG studies in various disease areas. These include malignant melanoma, breast cancer, primary liver cancer, mesothelioma, and esophagus cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA059307-06
Application #
2700499
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Program Officer
Kaplan, Richard S
Project Start
1994-08-08
Project End
1999-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pretoria
Department
Type
DUNS #
City
Pretoria
State
Country
South Africa
Zip Code
0002
Wolff, Antonio C; Wang, Molin; Li, Hailun et al. (2010) Phase II trial of pegylated liposomal doxorubicin plus docetaxel with and without trastuzumab in metastatic breast cancer: Eastern Cooperative Oncology Group trial E3198. Breast Cancer Res Treat 121:111-20
Kyle, Robert A; Jacobus, Susanna; Friedenberg, William R et al. (2009) The treatment of multiple myeloma using vincristine, carmustine, melphalan, cyclophosphamide, and prednisone (VBMCP) alternating with high-dose cyclophosphamide and alpha(2)beta interferon versus VBMCP: results of a phase III Eastern Cooperative Oncology Cancer 115:2155-64
Flinn, Ian W; Neuberg, Donna S; Grever, Michael R et al. (2007) Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol 25:793-8
Messing, Edward M; Manola, Judith; Yao, Jorge et al. (2006) Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy. Lancet Oncol 7:472-9
Byrd, John C; Rai, Kanti; Peterson, Bercedis L et al. (2005) Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 105:49-53
Okuno, Scott; Ryan, Louise M; Edmonson, John H et al. (2003) Phase II trial of gemcitabine in patients with advanced sarcomas (E1797): a trial of the Eastern Cooperative Oncology Group. Cancer 97:1969-73
Obasaju, C; Manola, J; Hudes, G R et al. (2001) Phase II evaluation of menogaril in advanced prostate cancer: Eastern Cooperative Oncology Group EST P-A885. Am J Clin Oncol 24:150-4
Giantonio, B J; Hochster, H; Blum, R et al. (2001) Toxicity and response evaluation of the interferon inducer poly ICLC administered at low dose in advanced renal carcinoma and relapsed or refractory lymphoma: a report of two clinical trials of the Eastern Cooperative Oncology Group. Invest New Drugs 19:89-92
Leaf, A N; Wolf, B C; Kirkwood, J M et al. (2000) Phase II study of etoposide (VP-16) in patients with thyroid cancer with no prior chemotherapy: an Eastern Cooperative Oncology Group Study (E1385). Med Oncol 17:47-51
Simpson, J F; Gray, R; Dressler, L G et al. (2000) Prognostic value of histologic grade and proliferative activity in axillary node-positive breast cancer: results from the Eastern Cooperative Oncology Group Companion Study, EST 4189. J Clin Oncol 18:2059-69