This is the first resubmission of a proposal to establish a Southeastern Duke Node in the NIDA National Drug Abuse Clinical Trials Network. We will partner with at least 10 real world community-based treatment programs (CTPs). The CTPs reflect diverse demographics; several are in rural or small town settings. CTPs will not only implement existing research protocols but will collaborate with Node scientists to develop new research concepts. The coordination of the CTPs and the interface with other Nodes and NIDA will be directed by a Regional Research and Training Center (RRTC) that represents a confederation of investigators, trainers and research monitors from Duke University Medical Center (DUMC) Department of Psychiatry, the Duke Clinical Research Institute (DCRI), and the National Development and Research Institutes (NDRI) each with their own strengths and a history of collaborating with each other. The RRTC will maintain the clinical infrastructure and the research infrastructure and will be responsible for all aspects of conducting clinical trials. Concept research proposals that can utilize the unique scope of the CTN are delineated: 1) Multi-modal CBT for adolescent substance abusers with internalizing disorders and 2) Selegiline/CBT for cocaine dependence. To enhance our contribution to the CTN's focus on multi-center, effectiveness research designs, we have designated Dr. Robert Hubbard as PI and added a cadre of DUMC-DCRI experts on effectiveness research who will broaden the inclusiveness, generalizability and usefulness of our studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10DA013711-03
Application #
6640599
Study Section
Special Emphasis Panel (ZDA1-WXG-F (27))
Program Officer
Shih, Ming L
Project Start
2001-01-10
Project End
2005-12-31
Budget Start
2003-01-01
Budget End
2003-12-31
Support Year
3
Fiscal Year
2003
Total Cost
$1,551,803
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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