Although cryotherapy as a treatment for severe ROP has been proven significantly effective in preserving vision among children who were born prematurely with birth weights below 1251 grams, there is reason to expect mounting complications over the years in eyes that had severe ROP, whether treated or untreated. As follow-up has continued into school age, eyes damaged by ROP are developing new or more extensive retinal detachment, cataracts, and band keratopathy-all conditions that not only can worsen already poor vision, but also can cause ocular pain. As these children enter adolescence, there is particular concern that eyes with preserved vision will sustain late retinal detachments or progressive photoreceptor failure, and consequent decline of visual acuity. This ongoing study affords the opportunity to ascertain whether the benefits of cryotherapy that accrued during early childhood will be sustained in adolescence. To determine this, an examination will be conducted at age 15 that will include objective masked assessment of both structure and function in treated and untreated eyes with severe ROP. An incidence comparison will be made between treated and untreated eyes for many sequelae and complications, such as late retinal detachment, macular degeneration, and vision failure.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY005874-16
Application #
6178452
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Everett, Donald F
Project Start
1990-06-01
Project End
2003-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
16
Fiscal Year
2000
Total Cost
$538,837
Indirect Cost
Name
Oregon Health and Science University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Siatkowski, R Michael; Dobson, Velma; Quinn, Graham E et al. (2007) Severe visual impairment in children with mild or moderate retinal residua following regressed threshold retinopathy of prematurity. J AAPOS 11:148-152
Dobson, Velma; Quinn, Graham E; Summers, C Gail et al. (2006) Visual acuity at 10 years in Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) study eyes: effect of retinal residua of retinopathy of prematurity. Arch Ophthalmol 124:199-202
Quinn, Graham E; Dobson, Velma; Saigal, Saroj et al. (2004) Health-related quality of life at age 10 years in very low-birth-weight children with and without threshold retinopathy of prematurity. Arch Ophthalmol 122:1659-66
Hardy, Robert J; Palmer, Earl A; Dobson, Velma et al. (2003) Risk analysis of prethreshold retinopathy of prematurity. Arch Ophthalmol 121:1697-701
Palmer, Earl A (2003) Implications of the natural course of retinopathy of prematurity. Pediatrics 111:885-6
Reynolds, James D; Dobson, Velma; Quinn, Graham E et al. (2002) Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies. Arch Ophthalmol 120:1470-6
Cryotherapy for Retinopathy of Prematurity Cooperative Group (2001) Effect of retinal ablative therapy for threshold retinopathy of prematurity: results of Goldmann perimetry at the age of 10 years. Arch Ophthalmol 119:1120-5
Cryotherapy for Retinopathy of Prematurity Cooperative Group (2001) Contrast sensitivity at age 10 years in children who had threshold retinopathy of prematurity. Arch Ophthalmol 119:1129-33
Repka, M X; Palmer, E A; Tung, B (2000) Involution of retinopathy of prematurity. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthalmol 118:645-9
Dobson, V; Quinn, G E; Siatkowski, R M et al. (1999) Agreement between grating acuity at age 1 year and Snellen acuity at age 5.5 years in the preterm child. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Invest Ophthalmol Vis Sci 40:496-503

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