This proposal describes the examination of a large cohort of persons who are at high risk for age-related macular degeneration (AMD) by virtue of their age. The cohort will have been under observation for 20 years allowing us to capitalize on the unique ability to: (1) determine the association of AMD with long and varying exposure to risk factors, some measured from the baseline examination (e.g., blood pressure, smoking, cardiovascular disease, markers of anti-oxidant stress) and some measured from 5, 10, or 15 years prior to the current examination (e.g., carotid artery intima-media thickness and plaques peak expiratory flow rate) as well as with changes in exposure levels over past time intervals;(2) determine the risk of AMD associated with specific polymorphisms in known and novel gene regions and to estimate population attributable risk for these sites;(3) determine gene/environment and gene/host interactions for AMD in the Beaver Dam cohort and in a pooled data set from 3 populations (Beaver Dam, Blue Mountains and Rotterdam) of European ancestry;and (4) examine the natural history of AMD and other retinal diseases (e.g., retinal vein occlusion;diabetic retinopathy) through cumulative 20 year incidence, regression, progression, age-period-cohort models and transitional state models. This approach is crucial for chronic diseases where risk factors are likely to exert their influence over a long period of time and where important ocular events evolve over a prolonged interval. This unique study will permit us to investigate new hypotheses about the correlates of AMD and other less common visually impairing retinal conditions. The information we will gain is of importance in understanding determinants of these retinal diseases and is needed for early diagnosis, prognosis, and for developing interventions to prevent visual loss from these conditions.
| Schubert, Carla R; Paulsen, Adam J; Nondahl, David M et al. (2018) Association Between Cystatin C and 20-Year Cumulative Incidence of Hearing Impairment in the Epidemiology of Hearing Loss Study. JAMA Otolaryngol Head Neck Surg 144:469-474 |
| Joo, Yoonmee; Cruickshanks, Karen J; Klein, Barbara E K et al. (2018) Prevalence of ototoxic medication use among older adults in Beaver Dam, Wisconsin. J Am Assoc Nurse Pract 30:27-34 |
| Loomis, Stephanie J; Klein, Alison P; Lee, Kristine E et al. (2018) Exome Array Analysis of Nuclear Lens Opacity. Ophthalmic Epidemiol 25:215-219 |
| Fischer, Mary E; Cruickshanks, Karen J; Dillard, Lauren K et al. (2018) An Epidemiologic Study of the Association between Free Recall Dichotic Digits Test Performance and Vascular Health. J Am Acad Audiol : |
| Holzinger, Emily R; Verma, Shefali S; Moore, Carrie B et al. (2017) Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min 10:25 |
| Chen, Yanjun; Nondahl, David M; Schubert, Carla R et al. (2017) The Relation between Sleep Disruption and Cataract in a Large Population-Based Study. Ophthalmic Epidemiol 24:111-115 |
| Schubert, Carla R; Fischer, Mary E; Pinto, A Alex et al. (2017) Sensory Impairments and Risk of Mortality in Older Adults. J Gerontol A Biol Sci Med Sci 72:710-715 |
| Klein, Ronald; Lee, Kristine E; Maynard, John D et al. (2017) Skin Intrinsic Fluorescence and Age-Related Macular Degeneration: The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 58:6328-6333 |
| Grassmann, Felix; Kiel, Christina; Zimmermann, Martina E et al. (2017) Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med 9:29 |
| Thomas, Bernadette; Matsushita, Kunihiro; Abate, Kalkidan Hassen et al. (2017) Global Cardiovascular and Renal Outcomes of Reduced GFR. J Am Soc Nephrol 28:2167-2179 |
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