The objectives of the Barbados Incidence Study of Eye Diseases (BISED) are: (1) to determine the incidence and progression of open-angle glaucoma, age- related cataract, diabetic retinopathy and age-related macular degeneration, (2) to evaluate risk factors for the incidence of the above eye diseases, using baseline data collected during the previous Barbados Eye Study (BES) examination, and (3) to determine the incidence and progression of visual acuity impairment and their associated factors This proposal outlines the rationale for and function of the BISED Fundus Photography Reading Center (FPRC). The FPRC will provide data to classify fundus photographs in a standardized manner. The FPRC will evaluate the fundus photographs of all participants in the incidence study according to the same grading scheme used in the prevalence study, which evaluates the optic disc for glaucomatous changes and the macula for diabetic and age- related changes. The gradings from the two studies will be compared to identify participants with newly identified pathology or changes in previous pathology. In addition to repeating the prevalence grading protocol, an additional side-by-side comparison grading will be performed to identify progression of disease pathology not presently included in the prevalence study grading scheme. The FPRC personnel who attained excellent reproducibility (measured by Kappa statistics) with the original BES grading scheme, remain on staff. Findings from clinical examinations are notoriously variable. Incorporation of data from the FPRC improves the quality of the study by supplying reproducible independent gradings on all photographed participants. Since the BES protocol does not refer everyone for ophthalmic examination, the photographic findings will be the only ophthalmic finding on approximately 1/4 of the participants.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10EY007617-05
Application #
3559593
Study Section
Vision Research and Training Committee (VSN)
Project Start
1987-09-30
Project End
1997-03-31
Budget Start
1992-06-01
Budget End
1993-03-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Leske, M Cristina; Wu, Suh-Yuh; Nemesure, Barbara et al. (2011) Incident open-angle glaucoma and ocular perfusion pressure. Invest Ophthalmol Vis Sci 52:7943
Hennis, Anselm J; Wu, Suh-Yuh; Nemesure, Barbara et al. (2009) Nine-year incidence of visual impairment in the Barbados Eye Studies. Ophthalmology 116:1461-8
Leske, M Cristina (2009) Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings. Curr Opin Ophthalmol 20:73-8
Wu, Suh-Yuh; Nemesure, Barbara; Hennis, Anselm et al. (2008) Open-angle glaucoma and mortality: The Barbados Eye Studies. Arch Ophthalmol 126:365-70
Wu, Suh-Yuh; Hennis, Anselm; Nemesure, Barbara et al. (2008) Impact of glaucoma, lens opacities, and cataract surgery on visual functioning and related quality of life: the Barbados Eye Studies. Invest Ophthalmol Vis Sci 49:1333-8
Leske, M Cristina; Wu, Suh-Yuh; Hennis, Anselm et al. (2008) Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology 115:85-93
Nemesure, Barbara; Wu, Suh-Yuh; Hennis, Anselm et al. (2007) Prevalence of obesity and associated sex-specific factors in an African-origin population. Ethn Dis 17:508-14
Hennis, Anselm; Wu, Suh-Yuh; Nemesure, Barbara et al. (2007) Awareness of incident open-angle glaucoma in a population study: the Barbados Eye Studies. Ophthalmology 114:1816-21
Leske, M Cristina; Wu, S Y; Honkanen, R et al. (2007) Nine-year incidence of open-angle glaucoma in the Barbados Eye Studies. Ophthalmology 114:1058-64
Nemesure, B; Honkanen, R; Hennis, A et al. (2007) Incident open-angle glaucoma and intraocular pressure. Ophthalmology 114:1810-5

Showing the most recent 10 out of 42 publications