The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Photography Reading Center (CPRC) provides objective, independent photographic verification of two important components of the CLEK Study: 1.) the presence, absence, and degree of severity of corneal scarring in all study eyes and, 2.) the rigid contact lens fit (fluorescein pattern) in all study eyes that wear rigid contact lenses, as well for the first rigid contact lens base curve that provides clearance of the corneal apex. This proposal provides documentation of the CPRC's ability to perform these functions with high sensitivity and specificity. This proposal also provides a description of the day-to-day organization of work, quality control and data management procedures required to insure the scientific integrity of the CLEK Study and to insure the orderly operation of the CPRC. Documentation of the capabilities of the proposed CPRC Staff for the performance of the Study in accord with the details of the CPRC Operations Manual and with the CLEK Study Operations Manual is provided.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY010069-05
Application #
2711080
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1994-09-30
Project End
2004-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Godefrooij, D A; de Wit, G A; Mangen, M J et al. (2016) Comment on 'Cost effectiveness of collagen crosslinking for progressive keratoconus in the UK NHS'. Eye (Lond) 30:1150-2
Jones-Jordan, Lisa A; Walline, Jeffrey J; Sinnott, Loraine T et al. (2013) Asymmetry in keratoconus and vision-related quality of life. Cornea 32:267-72
Fink, Barbara A; Sinnott, Loraine T; Wagner, Heidi et al. (2010) The influence of gender and hormone status on the severity and progression of keratoconus. Cornea 29:65-72
Kymes, Steven M; Walline, Jeffrey J; Zadnik, Karla et al. (2008) Changes in the quality-of-life of people with keratoconus. Am J Ophthalmol 145:611-617
Mahmoud, Ashraf M; Roberts, Cynthia J; Lembach, Richard G et al. (2008) CLMI: the cone location and magnitude index. Cornea 27:480-7
Szczotka-Flynn, L; Slaughter, M; McMahon, T et al. (2008) Disease severity and family history in keratoconus. Br J Ophthalmol 92:1108-11
Wagner, H; Barr, J T; Zadnik, K (2007) Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study: methods and findings to date. Cont Lens Anterior Eye 30:223-32
Davis, Larry J; Schechtman, Kenneth B; Wilson, Brad S et al. (2006) Longitudinal changes in visual acuity in keratoconus. Invest Ophthalmol Vis Sci 47:489-500
Barr, Joseph T; Wilson, Brad S; Gordon, Mae O et al. (2006) Estimation of the incidence and factors predictive of corneal scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Cornea 25:16-25
Gordon, Mae O; Steger-May, Karen; Szczotka-Flynn, Loretta et al. (2006) Baseline factors predictive of incident penetrating keratoplasty in keratoconus. Am J Ophthalmol 142:923-30

Showing the most recent 10 out of 32 publications