The Department of Obstetrics and Gynecology at the University of Tennessee, Memphis has been part of the Maternal-Fetal Medicine Network since April 1986. With this application, we hope to participate in a large multicenter network designed to develop and conduct clinical trials in the field of Maternal-Fetal Medicine, which could not be undertaken in a single center. In comparison to our previous application, we have recently expanded our resources and facilities to include patients at all major hospitals in the city. The obstetric population will now total approximately 13,000 women of various ethnic and economic groups. We are particularly interested in pursuing trials which require large sample size in order to adequately address specific questions and those regarding rare events of obstetric interest. The Principal Investigator, Dr. Baha Sibai, and the Alternate Principal Investigator, Dr. Brian Mercer, as well as the faculty in the Division of Maternal-Fetal Medicine continue to be active in Network administrative activities, and the design and conduct of protocols. The Principal Investigator currently participates on the Concurrent Research Committee, the Ad Hoc Committee on Preterm Studies, and the """"""""High-Risk"""""""" Aspirin Protocol, the Interim Progesterone, and the Preliminary Terbutaline subcommittees. The Alternate Principal Investigator chairs the """"""""Premature Rupture of Membranes"""""""" protocol and the Chart Review Subcommittee. He serves on the Capitation Subcommittee, Preterm PROM Pathology Subcommittee, Preterm Prediction Protocol Subcommittee, Obstetrical Determinants of Neonatal Survival Protocol Subcommittee, Neural Tube Defect Protocol Subcommittee and the Preliminary MgSO4 Subcommittee. He has recently submitted for consideration a clinical trial regarding tocolytic, corticosteroid and antimicrobial therapy after PROM. We are applying to continue as a clinical research center within the Network and agree to join protocols in existence and participate in the design of protocols in cooperation with other centers selected by the NICHD. The University of Tennessee, Memphis, and the Department of Obstetrics and Gynecology are committed to collaborative Maternal-Fetal research as documented by listed publications and the enclosed letters of commitment. The Division of Maternal-Fetal Medicine agrees to cooperate with the policy of capitation of research costs for each individual protocol, in addition to a base budget.

Project Start
1996-05-05
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
13
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
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Hirtz, Deborah G; Weiner, Steven J; Bulas, Dorothy et al. (2015) Antenatal Magnesium and Cerebral Palsy in Preterm Infants. J Pediatr 167:834-839.e3
Horton, Amanda L; Lai, Yinglei; Rouse, Dwight J et al. (2015) Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes. Am J Perinatol 32:387-92
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Peaceman, Alan M; Lai, Yinglei; Rouse, Dwight J et al. (2015) Length of latency with preterm premature rupture of membranes before 32 weeks' gestation. Am J Perinatol 32:57-62
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Graves, Steven W; Esplin, Michael S; McGee, Paula et al. (2014) Association of cord blood digitalis-like factor and necrotizing enterocolitis. Am J Obstet Gynecol 210:328.e1-328.e5
Sorokin, Yoram; Romero, Roberto; Mele, Lisa et al. (2014) Umbilical cord serum interleukin-6, C-reactive protein, and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes. Am J Perinatol 31:717-26
Chiossi, Giuseppe; Lai, Yinglei; Landon, Mark B et al. (2013) Timing of delivery and adverse outcomes in term singleton repeat cesarean deliveries. Obstet Gynecol 121:561-9
Andres, Robert L; Zhao, Yuan; Klebanoff, Mark A et al. (2013) The impact of tobacco use on preterm premature rupture of the membranes. Am J Perinatol 30:185-90

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