This proposal is a competitive renewal for Ohio State University?s participation in the Cooperative Multicenter Maternal-Fetal Medicine Units Network. The purpose of the Network is to investigate problems in clinical obstetrics, particularly those related to prevention of low birth weight, prematurity, and medical problems of pregnancy. The investigators have been a member of the MFMU Network for the past eight years. In this proposal they have described the academic productivity of the members of their research team specifically during the past four years in the Network, but also major accomplishments during the preceding four years. The investigators have also provided current information about their population and facilities. For their concept, they propose a prospective randomized trial of medication and bed rest versus placebo in women who have a history of preterm birth, a positive fibronectin, and a cervical length less than 35 mm at 22-24 weeks. The primary hypothesis is that treatment with bed rest and medication will reduce the rate of recurrent preterm birth by 50% compared with placebo, medication and no bed rest in this group of women. The investigators are committed to working cooperatively with Network staff and member units in identifying priority issues for research, developing and implementing protocols, collecting and transmitting quality data in a timely manner, and analyzing and publishing results of MFMU trials.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD027915-13
Application #
6746968
Study Section
Special Emphasis Panel (ZHD1-RRG-K (09))
Program Officer
Spong, Catherine
Project Start
1992-04-08
Project End
2006-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
13
Fiscal Year
2004
Total Cost
$766,831
Indirect Cost
Name
Ohio State University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Pasko, Daniel N; McGee, Paula; Grobman, William A et al. (2018) Variation in the Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rate. Obstet Gynecol 131:1039-1048
Tita, Alan T N; Jablonski, Kathleen A; Bailit, Jennifer L et al. (2018) Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 219:296.e1-296.e8
Grobman, William A; Bailit, Jennifer; Sandoval, Grecio et al. (2018) The Association of Decision-to-Incision Time for Cesarean Delivery with Maternal and Neonatal Outcomes. Am J Perinatol 35:247-253
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Chauhan, Suneet P; Weiner, Steven J; Saade, George R et al. (2018) Intrapartum Fetal Heart Rate Tracing Among Small-for-Gestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol 132:1019-1025
Kominiarek, Michelle A; Saade, George; Mele, Lisa et al. (2018) Association Between Gestational Weight Gain and Perinatal Outcomes. Obstet Gynecol 132:875-881
Kominiarek, Michelle A; Smid, Marcela C; Mele, Lisa et al. (2018) Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. Obstet Gynecol 132:1386-1393
Varner, Michael W; Mele, Lisa; Casey, Brian M et al. (2018) Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. J Perinatol 38:1490-1495

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