Continuation of the Vanderbilt Center for Education and Research in Therapeutics (CERT) is proposed as part of a national collaboration to systematically improve pharmacotherapy. The theme of the Vanderbilt CERT is Encouraging Optimal Therapeutics in Medicaid and Veteran's Health Administration Populations, populations particularly vulnerable to suboptimal pharmacotherapy, underrepresented in research for a variety of reasons, and affected by managed care policies that may adversely affect therapeutics. Vulnerable groups encompassed by the CERT focus include the developing fetus, young children, low-income mothers, African Americans and other minorities, persons with mental and somatic disabilities, the chronically ill, the elderly, and persons in nursing homes. The Vanderbilt CERT realizes its mission by conducting interdisciplinary projects in conjunction with our partners that have the following 4 specific aims: 1. Improve the knowledge base for therapeutics by conducting studies of drug effects;2. Identify suboptimal provider or patient therapeutic practices;3. Conduct focused educational programs to improve therapeutics;4. Evaluate the impact of health care payer policies that may affect therapeutics. In its first three years, the Vanderbilt CERT has created an administrative infrastructure, organized 4 thematic investigator groups, and developed a collaborative network with 12 faculty. It has established strong partnerships with the State of Tennessee, the Tennessee Quality Improvement Organization, the Veteran's Administration Tennessee Valley Healthcare System and Geriatric Research, Education and Clinical Center, and the Food and Drug Administration. It has conducted 25 core projects that to date have resulted in 14 publications, 7 manuscripts under review, and 4 in preparation; and has 51 leveraged publications. In the upcoming cycle, the CERT will conduct 10 core projects and 3 partner-oriented, educational outreach/service activities. The multi-disciplinary projects include 7 research studies designed to inform provider and patient decision making in areas of clinical controversy and 3 educational programs underpinned by evidence-based guidelines and designed to reduce inappropriate variations in care. The projects include substantial representation of women, minorities, and children; and focus on high-cost disease states that are important to Medicaid, Medicare, and other federal health programs.

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Demonstration--Cooperative Agreements (U18)
Project #
5U18HS010384-06
Application #
6804441
Study Section
Special Emphasis Panel (ZHS1-HSR-O (01))
Program Officer
Bosco, Lynn
Project Start
1999-09-30
Project End
2007-09-29
Budget Start
2004-09-30
Budget End
2005-09-29
Support Year
6
Fiscal Year
2004
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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Eckrich, Michael J; Wang, Winfred C; Yang, Elizabeth et al. (2013) Adherence to transcranial Doppler screening guidelines among children with sickle cell disease. Pediatr Blood Cancer 60:270-4
Ray, Wayne A; Murray, Katherine T; Hall, Kathi et al. (2012) Azithromycin and the risk of cardiovascular death. N Engl J Med 366:1881-90
Bobo, William V; Cooper, William O; Epstein Jr, Richard A et al. (2011) Positive predictive value of automated database records for diabetic ketoacidosis (DKA) in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid Study. BMC Med Res Methodol 11:157
Ray, Wayne A; Chung, Cecilia P; Murray, Katherine T et al. (2009) Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 360:225-35
Arbogast, Patrick G; Ray, Wayne A (2009) Use of disease risk scores in pharmacoepidemiologic studies. Stat Methods Med Res 18:67-80
Moore, Paul E; Williams, Scott M; Gebretsadik, Tebeb et al. (2008) beta(2)-adrenergic receptor promoter haplotype influences spirometric response during an acute asthma exacerbation. Clin Transl Sci 1:155-61
Cooper, William O; Ray, Wayne A; Arbogast, Patrick G et al. (2008) Health plan notification and feedback to providers is associated with increased filling of preventer medications for children with asthma enrolled in Medicaid. J Pediatr 152:481-8
Carroll, Kecia N; Gebretsadik, Tebeb; Griffin, Marie R et al. (2008) Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan. Pediatrics 122:58-64
Asad, Shaheena; Hulgan, Todd; Raffanti, Stephen P et al. (2008) Sociodemographic factors predict early discontinuation of HIV non-nucleoside reverse transcriptase inhibitors and protease inhibitors. J Natl Med Assoc 100:1417-24

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