Abstract

We propose a Program Project to investigate the genetics of longevity in humans and in model organisms. The application includes six distinct research projects, and three cores (Administrative, Biostatistics and Bioinformatics, and Genomics). Details are provided below.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AG023122-04
Application #
7256964
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (O2))
Program Officer
Rossi, Winifred K
Project Start
2004-09-30
Project End
2009-06-30
Budget Start
2007-07-15
Budget End
2008-06-30
Support Year
4
Fiscal Year
2007
Total Cost
$3,156,560
Indirect Cost

  Institution

Name
California Pacific Medical Center Research Institute
Department
Type
DUNS #
071882724
City
San Francisco
State
CA
Country
United States
Zip Code
94107

  Publications

Brown, Abigail K; Webb, Ashley E (2018) Regulation of FOXO Factors in Mammalian Cells. Curr Top Dev Biol 127:165-192
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2018) Sex Differences in Genetic Associations With Longevity. JAMA Netw Open 1:
Schork, Nicholas J; Raghavachari, Nalini; Workshop Speakers and Participants (2018) Report: NIA workshop on translating genetic variants associated with longevity into drug targets. Geroscience 40:523-538
Ding, Kuan-Fu; Finlay, Darren; Yin, Hongwei et al. (2018) Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients. Front Genet 9:228
Ding, Kuan-Fu; Petricoin, Emanuel F; Finlay, Darren et al. (2018) Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis. Oncotarget 9:5044-5057
Perls, Thomas T (2017) Male Centenarians: How and Why Are They Different from Their Female Counterparts? J Am Geriatr Soc 65:1904-1906
Pickering, Andrew M; Lehr, Marcus; Gendron, Christi M et al. (2017) Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. Aging Cell 16:683-692
Ding, Kuan-Fu; Finlay, Darren; Yin, Hongwei et al. (2017) Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses. Oncotarget 8:27786-27799
Sebastiani, Paola; Bae, Harold; Gurinovich, Anastasia et al. (2017) Limitations and risks of meta-analyses of longevity studies. Mech Ageing Dev 165:139-146
Sebastiani, Paola; Thyagarajan, Bharat; Sun, Fangui et al. (2017) Biomarker signatures of aging. Aging Cell 16:329-338

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