The overall goal of the Alzheimer's Disease (AD) Neuroimaging Initiative (ADNI) is to discover, standardize, and validate biomarkers for AD treatment trials. Validation is accomplished by comparing and correlating clinical/cognitive with biomarker data. Impact of ADNI has been to optimize, standardize and validate biomarkers, especially brain amyloid by PET and CSF measurements of A? peptides, termed ?A? amyloid- phenotyping.? There are 907 papers published using ADNI data. We will follow-up with annual visits, 697 subjects previously enrolled in ADNI2 (cognitively normal controls, subjects currently enrolled subjects with MCI, and patients with dementia diagnosed as AD) and will enroll 371 new subjects, while collecting clinical, cognitive, MRI (structural, diffusion, perfusion, resting state), amyloid PET, FDG PET, cerebrospinal fluid (for a A?, tau, phosphotau, and other proteins), genetic and autopsy data. In addition longitudinal measurements of brain tau PET will be performed on all subjects. All data is available without embargo to from USC/LONI/ADNI.
Specific Aims : 1. Longitudinal changes in cognition and associated biomarkers: To determine those measures of cognition and function, including composite measures, and those biomarker measures which best capture longitudinal change with highest statistical power to detect treatment effects in clinical trials. Longitudinal change of brain tau tangles measured with tau PET will be correlated/compared with other measures. 2. Prediction of cognitive decline: To determine the clinical, cognitive, and biomarker measures which best predict decline of cognition in cognitively normal controls, subjects with MCI, and patients with dementia. In addition, to determine those biomarkers, especially tau PET, which correlate with cognitive decline. 3. Validation: To validate biomarker measures obtained at baseline and longitudinally by correlating results with ?gold standard? clinical measurements and pathology. 4. Clinical trial design: To determine the optimum outcome measures (especially rate of cognitive decline and tau PET), predictors of cognitive decline, and inclusion/exclusion criteria for clinical trials of cognitively normal subjects (for secondary preclinical AD trials) and MCI patients (for prodromal AD trials). 5. Discovery: To determine the effects of other known disease proteins found in AD brains (e.g. alpha- synuclein, TDP 43,progranulin) and genes, and newly discovered proteins (from proteinomics), genes,and other analytes (from metabolomics) which provide useful information concerning the pathogenesis/diagnosis of AD. Discovery is conducted through the add-on studies led/driven by ADNI investigators with oversight by the NIA and the ADNI Resource Allocation Review Committee (RARC). ADNI methods and data are used in study design by government and industry funded clinical trials. Continuation of ADNI will help lead to development of effective treatments which slow progression and prevent AD.

Public Health Relevance

Alzheimer's disease (AD) causes cognitive impairment and dementia in millions of Americans and costs more than $100 billion/year in the USA. The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a large multisite public private partnership that will validate brain imaging, blood tests, and other diagnostics. This initiative will greatly facilitate design of clinical treatment trials and will help develop new diagnostic techniques, which identify AD at an early stage, ultimately leading to effective treatment and prevention of AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AG024904-15
Application #
9994139
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Ryan, Laurie M
Project Start
2004-09-30
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
15
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Northern California Institute Research & Education
Department
Type
DUNS #
613338789
City
San Francisco
State
CA
Country
United States
Zip Code
94121
Properzi, Michael J; Buckley, Rachel F; Chhatwal, Jasmeer P et al. (2018) Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. Neuroimage 186:446-454
Zigon, Bob; Li, Huang; Yao, Xiaohui et al. (2018) GPU Accelerated Browser for Neuroimaging Genomics. Neuroinformatics 16:393-402
Lee, Catherine; Betensky, Rebecca A; Alzheimer's Disease Neuroimaging Initiative (2018) Time-to-event data with time-varying biomarkers measured only at study entry, with applications to Alzheimer's disease. Stat Med 37:914-932
Cruchaga, Carlos; Del-Aguila, Jorge L; Saef, Benjamin et al. (2018) Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement 14:205-214
Kim, Hosung; Caldairou, Benoit; Bernasconi, Andrea et al. (2018) Multi-Template Mesiotemporal Lobe Segmentation: Effects of Surface and Volume Feature Modeling. Front Neuroinform 12:39
Weiner, Michael W; Nosheny, Rachel; Camacho, Monica et al. (2018) The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies. Alzheimers Dement 14:1063-1076
Henriques, Adriane Dallanora; Benedet, Andrea Lessa; Camargos, Einstein Francisco et al. (2018) Fluid and imaging biomarkers for Alzheimer's disease: Where we stand and where to head to. Exp Gerontol 107:169-177
Cong, Shan; Risacher, Shannon L; West, John D et al. (2018) Volumetric comparison of hippocampal subfields extracted from 4-minute accelerated vs. 8-minute high-resolution T2-weighted 3T MRI scans. Brain Imaging Behav 12:1583-1595
Oltra-Cucarella, Javier; Sánchez-SanSegundo, Miriam; Lipnicki, Darren M et al. (2018) Using Base Rate of Low Scores to Identify Progression from Amnestic Mild Cognitive Impairment to Alzheimer's Disease. J Am Geriatr Soc 66:1360-1366
Swanson, Ashley; Wolf, Tovah; Sitzmann, Alli et al. (2018) Neuroinflammation in Alzheimer's disease: Pleiotropic roles for cytokines and neuronal pentraxins. Behav Brain Res 347:49-56

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