Abstract

The overall objective of the Spectratyping Core is to perform the TCR Vp CDR3-size spectratype analysis on relevant samples supplied by program Projects, and provide expertise for data analysis and interpretation. This Core will conduct molecular evaluation of the T cell repertoires from the presented samples as they relate to immunological reconstitution and regulation, as well as both alloreactive and tumor-reactive responses following allogeneic blood and marrow transplantation (BMT) in both clinical and experimental settings. Because the Core leader has extensive experience with this technology this Core will serve as an interactive resource for several aspects of the three projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI029530-16
Application #
7409146
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
16
Fiscal Year
2007
Total Cost
$251,406
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Kim, Haesook T; Zhang, Mei-Jie; Woolfrey, Ann E et al. (2016) Donor and recipient sex in allogeneic stem cell transplantation: what really matters. Haematologica 101:1260-1266
Armand, Philippe; Kim, Haesook T; Sainvil, Marie-Michele et al. (2016) The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. Br J Haematol 173:96-104
Armand, Philippe; Kim, Haesook T; Logan, Brent R et al. (2014) Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation. Blood 123:3664-71
Armand, Philippe; Kim, Haesook T; Virtanen, Johanna M et al. (2014) Iron overload in allogeneic hematopoietic cell transplantation outcome: a meta-analysis. Biol Blood Marrow Transplant 20:1248-51
Kim, Haesook T; Armand, Philippe (2013) Clinical endpoints in allogeneic hematopoietic stem cell transplantation studies: the cost of freedom. Biol Blood Marrow Transplant 19:860-6
Matsuoka, Ken-ichi; Koreth, John; Kim, Haesook T et al. (2013) Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med 5:179ra43
Armand, Philippe; Gibson, Christopher J; Cutler, Corey et al. (2012) A disease risk index for patients undergoing allogeneic stem cell transplantation. Blood 120:905-13
Armand, Philippe; Kim, Haesook T; Zhang, Mei-Jie et al. (2012) Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a Center for International Blood and Marrow Transplant Research study. Biol Blood Marrow Transplant 18:280-8
Zilberberg, Jenny; Friedman, Thea M; Dranoff, Glenn et al. (2011) Treatment with GM-CSF secreting myeloid leukemia cell vaccine prior to autologous-BMT improves the survival of leukemia-challenged mice. Biol Blood Marrow Transplant 17:330-40
Kawano, Yutaka; Kim, Haesook T; Matsuoka, Ken-Ichi et al. (2011) Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation. Blood 118:5021-30

Showing the most recent 10 out of 25 publications