The proposed research is focused on STD transmission within sexual dyads and on factors associated with early subsequent infections (those occurring within one month of initial infection). This focus allows comparison of uninfected with infected dyads, evaluation of factors from each partner associated with within-dyad transmission (assessed at the time of enrollment) and subsequent infection (within one month of initial infection.). Partner agreement on key STD risk and protective behaviors is also assessed. Organisms of interest are N. gonorrhoeae, C. trachomatis and T. vaginalis. Enrollment and evaluation of new partners allows more complete assessment of factors related to early reinfection. In dyads where both members are infected by gonorrhea, concordant opa-types establishes within-dyad transmission. In dyads where both members are infected by chlamydia, identical omp-1 DNA sequences suggests that the source of infection is within-dyad. Discordant opa-type or omp-1 DNA sequence established the source of infection as extra-dyadic. Concordance for trichomonas infection will be assessed by polymerase chain reaction. Overall, the research is expected to provide data of key importance for the implementation of more effective STD screening and treatment programs, especially those focused on high risk adolescents and young adults.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI031494-10
Application #
6348895
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
Budget End
Support Year
10
Fiscal Year
2000
Total Cost
$137,421
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Hensel, Devon J; Nance, Jennifer; Fortenberry, J Dennis (2016) The Association Between Sexual Health and Physical, Mental, and Social Health in Adolescent Women. J Adolesc Health 59:416-21
Hensel, Devon J; Selby, Sarah; Tanner, Amanda E et al. (2016) A Daily Diary Analysis of Condom Breakage and Slippage During Vaginal Sex or Anal Sex Among Adolescent Women. Sex Transm Dis 43:531-6
Hensel, Devon J; Tanner, Amanda E; Sherrow, Ashley et al. (2016) A longitudinal daily diary analysis of condom use during bleeding-associated vaginal sex among adolescent females. Sex Transm Infect 92:337-9
Singer, Martin; Li, Wei; Morré, Servaas A et al. (2016) Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers. J Infect Dis 214:489-95
van Rensburg, Julia J; Lin, Huaiying; Gao, Xiang et al. (2015) The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection. MBio 6:e01315-15
Bell, David L; Rosenberger, Joshua G; Ott, Mary A (2015) Masculinity in adolescent males' early romantic and sexual heterosexual relationships. Am J Mens Health 9:201-8
Li, Zhuokai; Liu, Hai; Tu, Wanzhu (2015) A sexually transmitted infection screening algorithm based on semiparametric regression models. Stat Med 34:2844-57
Janowicz, Diane M; Zwickl, Beth W; Fortney, Kate R et al. (2014) Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection. BMC Microbiol 14:166
Best, Candace; Tanner, Amanda E; Hensel, Devon J et al. (2014) Young women's contraceptive microbicide preferences: associations with contraceptive behavior and sexual relationship characteristics. Perspect Sex Reprod Health 46:15-22
Batteiger, Byron E; Wan, Raymond; Williams, James A et al. (2014) Novel Chlamydia trachomatis strains in heterosexual sex partners, Indianapolis, Indiana, USA. Emerg Infect Dis 20:1841-7

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