This continuation application proposes to extensively address two general questions about STI during the developmental transition from middle and late adolescence into young adulthood: 1) Describe the developmental epidemiology of four sexually transmitted organisms (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) among adolescent and young adult women and among their male sex partners; 2) examine patterns of infection acquisition, duration and resolution using weekly vaginal swabs over 12-week intensive observation periods. Data from the first question may inform relevant clinical and policy issues such as the initiation, frequency and duration of STI screening programs. Data from the second question could additionally inform issues related to prevention interventions and partner treatment, among others. Data will be collected from re-enrolled participants in current project and are between 14 - 21 years of age. Quarterly visits (over four years) and two 3- month intervals of daily diary and weekly vaginal swab collection will be merged with data collected during the current project period. New data allow focus on STI related issue in late adolescence and early young adulthood. Merged data from both projects (up to 75 months of follow-up) allows focus on a full developmental span from middle adolescence into young adulthood.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI031494-14
Application #
6842447
Study Section
Special Emphasis Panel (ZAI1-NBS-M (M4))
Project Start
2004-08-01
Project End
2009-07-31
Budget Start
2004-09-01
Budget End
2005-07-31
Support Year
14
Fiscal Year
2004
Total Cost
$83,346
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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Singer, Martin; Li, Wei; Morré, Servaas A et al. (2016) Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers. J Infect Dis 214:489-95
Hensel, Devon J; Nance, Jennifer; Fortenberry, J Dennis (2016) The Association Between Sexual Health and Physical, Mental, and Social Health in Adolescent Women. J Adolesc Health 59:416-21
Hensel, Devon J; Selby, Sarah; Tanner, Amanda E et al. (2016) A Daily Diary Analysis of Condom Breakage and Slippage During Vaginal Sex or Anal Sex Among Adolescent Women. Sex Transm Dis 43:531-6
van Rensburg, Julia J; Lin, Huaiying; Gao, Xiang et al. (2015) The Human Skin Microbiome Associates with the Outcome of and Is Influenced by Bacterial Infection. MBio 6:e01315-15
Bell, David L; Rosenberger, Joshua G; Ott, Mary A (2015) Masculinity in adolescent males' early romantic and sexual heterosexual relationships. Am J Mens Health 9:201-8
Li, Zhuokai; Liu, Hai; Tu, Wanzhu (2015) A sexually transmitted infection screening algorithm based on semiparametric regression models. Stat Med 34:2844-57
Janowicz, Diane M; Zwickl, Beth W; Fortney, Kate R et al. (2014) Outer membrane protein P4 is not required for virulence in the human challenge model of Haemophilus ducreyi infection. BMC Microbiol 14:166
Best, Candace; Tanner, Amanda E; Hensel, Devon J et al. (2014) Young women's contraceptive microbicide preferences: associations with contraceptive behavior and sexual relationship characteristics. Perspect Sex Reprod Health 46:15-22
Batteiger, Byron E; Wan, Raymond; Williams, James A et al. (2014) Novel Chlamydia trachomatis strains in heterosexual sex partners, Indianapolis, Indiana, USA. Emerg Infect Dis 20:1841-7

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