Abstract

This is a core clinical/microbiology facility which will interact with the behavioral and epidemiological studies and with the basic science as well as with other NIH supported research in Dr. Sparling's lab, which is not explicitly described in this proposal. The core will serve to link the arenas of epidemiology and behavioral science with those of microbiology and immunology. In particular, activities supported by this core will help to determine whether there is strain specific immunity in mucosal gonococcal infection. Identification of strains will be expanded to include restriction fragment length polymorphisms, in addition to auxotype and serotype. A total of 1500 gonococci will be typed by these techniques. Strain typing data also will be important to determination of sexual networks in the population studied in Project 6. The core will serve as a repository for serum and mucosal antibody specimens collected on clients seen at the Wilson County and Wake County STD Clinics and also for serum samples obtained from volunteers in the human inoculation studies describe in Project 3. These samples will be made available to investigators on basic science projects in this Center as well as other investigators at other institutions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI031496-08
Application #
6099531
Study Section
Project Start
1998-07-01
Project End
1999-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Zhu, Weiyan; Tomberg, Joshua; Knilans, Kayla J et al. (2018) Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation. J Biol Chem 293:11218-11229
Des Marais, Andrea C; Zhao, Yuqian; Hobbs, Marcia M et al. (2018) Home Self-Collection by Mail to Test for Human Papillomavirus and Sexually Transmitted Infections. Obstet Gynecol 132:1412-1420
Scheidell, Joy D; Beau De Rochars, Valery Madsen; Séraphin, Marie Nancy et al. (2018) Socioeconomic Vulnerability and Sexually Transmitted Infection Among Pregnant Haitian Women. Sex Transm Dis 45:626-631
Knilans, Kayla J; Hackett, Kathleen T; Anderson, James E et al. (2017) Neisseria gonorrhoeae Lytic Transglycosylases LtgA and LtgD Reduce Host Innate Immune Signaling through TLR2 and NOD2. ACS Infect Dis 3:624-633
Gallo, Maria F; Legardy-Williams, Jennifer; Steiner, Markus J et al. (2017) Sexual Relationship Power and Semen Exposure Among Female Patients at a Sexually Transmitted Infection Clinic in Kingston, Jamaica. Arch Sex Behav 46:2157-2164
Woolf-King, Sarah E; Muyindike, Winnie; Hobbs, Marcia M et al. (2017) Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women. AIDS Behav 21:2141-2146
Samo, Melissa; Choudhary, Neelima R; Riebe, Kristina J et al. (2016) Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface. Vaccine 34:1193-200
Kandler, Justin L; Acevedo, Rosuany Vélez; Dickinson, Mary Kathryne et al. (2016) The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions. Mol Microbiol 102:137-51
Kandler, Justin L; Holley, Concerta L; Reimche, Jennifer L et al. (2016) The MisR Response Regulator Is Necessary for Intrinsic Cationic Antimicrobial Peptide and Aminoglycoside Resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother 60:4690-700
Kissinger, Patricia J; White, Scott; Manhart, Lisa E et al. (2016) Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. Sex Transm Dis 43:599-602

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