Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI031718-06
Application #
2003710
Study Section
Special Emphasis Panel (SRC (74))
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Chen, Jiong J; Wei, Yuan; Williams, John D et al. (2005) Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides. Nucleosides Nucleotides Nucleic Acids 24:1417-37
Williams, John D; Drach, John C; Townsend, Leroy B (2005) Synthesis and antiviral activity of some 2-substituted 3-formyl- and 3-cyano-5,6-dichloroindole nucleosides. Nucleosides Nucleotides Nucleic Acids 24:1613-26
Migawa, Michael T; Drach, John C; Townsend, Leroy B (2005) Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7 J Med Chem 48:3840-51
Kern, Earl R; Hartline, Caroll B; Rybak, Rachel J et al. (2004) Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections. Antimicrob Agents Chemother 48:1749-55
Williams, John D; Chen, Jiong J; Drach, John C et al. (2004) Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides. J Med Chem 47:5753-65
Chien, Tun-Cheng; Saluja, Sunita S; Drach, John C et al. (2004) Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. J Med Chem 47:5743-52
Williams, John D; Ptak, Roger G; Drach, John C et al. (2004) Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides. J Med Chem 47:5773-82
Komazin, Gloria; Townsend, Leroy B; Drach, John C (2004) Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides. J Virol 78:710-5
Evers, David L; Komazin, Gloria; Ptak, Roger G et al. (2004) Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms. Antimicrob Agents Chemother 48:3918-27
Porcari, Anthony R; Townsend, Leroy B (2004) An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. Nucleosides Nucleotides Nucleic Acids 23:31-9

Showing the most recent 10 out of 39 publications