Abstract

This is a prospective 1.5-year longitudinal study of the course of illness in 100 subjects with chronic fatigue syndrome (CFS) or chronic fatigue (CF). CFS is characterized by fatigue, disability, and multiple physical and psychological symptoms. It is generally associated with a prolonged course. Subjects with CF have chronic fatigue with insufficient additional symptoms to fulfill CFS criteria. The goals of the study are to improve understanding of which factors are associated with recovery versus worsening of CFS/CF. The first specific goal of this study is to examine psychosocial factors hypothesized to be related to prognosis, i.e., a history of threatening life events (including a history of physical/sexual victimization), psychiatric illness and subclinical psychiatric symptoms, dysfunctional personality characteristics, coping style, social support and reactions of significant others in the patient's environment to the CFS/CF. The second goal of this Project is to examine the interaction effects of psychosocial variables and immune function in predicting the course of illness in CFS/CF.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI038429-03
Application #
6235363
Study Section
Project Start
1997-08-01
Project End
1998-07-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Mehalick, Melissa L; Schmaling, Karen B; Sabath, Daniel E et al. (2018) Longitudinal associations of lymphocyte subsets with clinical outcomes in chronic fatigue syndrome. Fatigue 6:80-91
Schmaling, Karen B; Betterton, Karran L (2016) Neurocognitive complaints and functional status among patients with chronic fatigue syndrome and fibromyalgia. Qual Life Res 25:1257-63
Romano, Joan M; Molton, Ivan R; Alschuler, Kevin N et al. (2016) Reported Pain and Fatigue Behaviors Mediate the Relationship Between Catastrophizing and Perceptions of Solicitousness in Patients With Chronic Fatigue. J Pain 17:328-35
Schmaling, Karen B; Romano, Joan M; Jensen, Mark P et al. (2015) Salivary cortisol responses to household tasks among couples with unexplained chronic fatigue. J Fam Psychol 29:296-301
Vitaliano, Peter P; Strachan, Eric; Dansie, Elizabeth et al. (2014) Does caregiving cause psychological distress? The case for familial and genetic vulnerabilities in female twins. Ann Behav Med 47:198-207
Poeschla, Brian; Strachan, Eric; Dansie, Elizabeth et al. (2013) Chronic fatigue and personality: a twin study of causal pathways and shared liabilities. Ann Behav Med 45:289-98
Dansie, Elizabeth J; Heppner, Pia; Furberg, Helena et al. (2012) The comorbidity of self-reported chronic fatigue syndrome, post-traumatic stress disorder, and traumatic symptoms. Psychosomatics 53:250-7
Dansie, Elizabeth J; Furberg, Helena; Afari, Niloofar et al. (2012) Conditions comorbid with chronic fatigue in a population-based sample. Psychosomatics 53:44-50
Wright, Lisa Johnson; Schur, Ellen; Noonan, Carolyn et al. (2010) Chronic pain, overweight, and obesity: findings from a community-based twin registry. J Pain 11:628-35
Smith, Mark S; Buchwald, Dedra S; Bogart, Andy et al. (2010) Adolescent offspring of mothers with chronic fatigue syndrome. J Adolesc Health 46:284-91

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