Abstract

Dr. S. Patrick Donegan, under Dr. Rice's supervision, will direct the Clinical core that will provide subjects including patient materials and epidemiologic information to each of the Projects to advance their scientific questions. The core patient groups will consist of women who are enrolled in in vitro fertilization programs at Brigham and Women's hospital, women who undergo endometrial biopsies at the BCH-STD-Clinic for suspected endometritis, and BCH-STD attendees who will enroll in behavioral intervention studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI038515-02
Application #
5205888
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Ketterer, Margaret R; Rice, Peter A; Gulati, Sunita et al. (2016) Desialylation of Neisseria gonorrhoeae Lipooligosaccharide by Cervicovaginal Microbiome Sialidases: The Potential for Enhancing Infectivity in Men. J Infect Dis 214:1621-1628
Agarwal, Sarika; Sebastian, Shite; Szmigielski, Borys et al. (2008) Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women. J Bacteriol 190:3129-39
Sagar, Manish; Wu, Xueling; Lee, Sandra et al. (2006) Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol 80:9586-98
Shen, Li; Feng, Xiaogeng; Yuan, Yuan et al. (2006) Selective promoter recognition by chlamydial sigma28 holoenzyme. J Bacteriol 188:7364-77
Sagar, Manish; Kirkegaard, Erin; Lavreys, Ludo et al. (2006) Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses 22:430-7
Wu, Hsing-Ju; Seib, Kate L; Srikhanta, Yogitha N et al. (2006) PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae. Mol Microbiol 60:401-16
Seib, Kate L; Wu, Hsing-Ju; Kidd, Stephen P et al. (2006) Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment. Microbiol Mol Biol Rev 70:344-61
Timmerman, Michelle M; Shao, Jian Q; Apicella, Michael A (2005) Ultrastructural analysis of the pathogenesis of Neisseria gonorrhoeae endometrial infection. Cell Microbiol 7:627-36
Porter, Edith; Yang, Huixia; Yavagal, Sujata et al. (2005) Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun 73:4823-33
Wu, Hsing-Ju; Seib, Kate L; Edwards, Jennifer L et al. (2005) Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells. Infect Immun 73:8444-8

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