The overall goal of Core C-Molecular Biology is to provide research, training and collaborative support for Projects 1, 2, and 3 of the ICIDR African Malaria Vectors. Core C currently exists as the ICIPE Department of Molecular Biology and Biotechnology (MBB). The Head of the Department, Dr. Ellie O. Osir, will also serve as the Core Leader. Core C has 3 specific aims: 1) to provide molecular biology research support for the 3 ICIDR projects: Larval Ecology, Behavior, and Vector Competence, 2) to provide training support for ICIDR team members and visiting national and international collaborators, and 3) to provide linkages with an international network of insect molecular biologists and to assist with publication of papers and presentations of research results. Some of the technical inputs that Core C will provide include PCR identification of Anopheles gambiae complex, the use of random amplified polymorphic DNA-PCR and microsatellite markers for studying the population genetics of Anopheles gambiae complex, QTL mapping if malaria-refractory genes in mosquitoes. Core C resources will be divided according to: 40% Project 1- Larval Ecology, 20% Project 2- Behavior, and 40% Project 3-Vector Competence. The Core Leader and staff of the MBB Department have extensive international linkages to well-recognized insect molecular biologists and physiologists. Many of these notable insect biologists are already helping ICIPE/MBB with other programs at the Nairobi laboratories. This ICIDR project will benefit from these professional contacts and we anticipate that this will have a major impact on the quality of the science.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI045511-04
Application #
6655151
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2002-09-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
$159,181
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Mwangangi, Joseph M; Mbogo, Charles M; Orindi, Benedict O et al. (2013) Shifts in malaria vector species composition and transmission dynamics along the Kenyan coast over the past 20 years. Malar J 12:13
Muiruri, Samuel K; Mwangangi, Joseph M; Carlson, John et al. (2013) Effect of predation on Anopheles larvae by five sympatric insect families in coastal Kenya. J Vector Borne Dis 50:45-50
Mireji, Paul O; Keating, Joseph; Hassanali, Ahmed et al. (2010) Expression of metallothionein and alpha-tubulin in heavy metal-tolerant Anopheles gambiae sensu stricto (Diptera: Culicidae). Ecotoxicol Environ Saf 73:46-50
Carlson, John C; Dyer, Lee A; Omlin, Francois X et al. (2009) Diversity cascades and malaria vectors. J Med Entomol 46:460-4
Magalhaes, T; Brackney, D E; Beier, J C et al. (2008) Silencing an Anopheles gambiae catalase and sulfhydryl oxidase increases mosquito mortality after a blood meal. Arch Insect Biochem Physiol 68:134-43
Sumba, Leunita A; Ogbunugafor, C Brandon; Deng, Arop L et al. (2008) Regulation of oviposition in Anopheles gambiae s.s.: role of inter- and intra-specific signals. J Chem Ecol 34:1430-6
Impoinvil, Daniel E; Keating, Joseph; Mbogo, Charles M et al. (2008) Abundance of immature Anopheles and culicines (Diptera: Culicidae) in different water body types in the urban environment of Malindi, Kenya. J Vector Ecol 33:107-16
Impoinvil, Daniel E; Mbogo, Charles M; Keating, Joseph et al. (2008) The role of unused swimming pools as a habitat for Anopheles immature stages in urban Malindi, Kenya. J Am Mosq Control Assoc 24:457-9
Mireji, Paul O; Keating, Joseph; Hassanali, Ahmed et al. (2008) Heavy metals in mosquito larval habitats in urban Kisumu and Malindi, Kenya, and their impact. Ecotoxicol Environ Saf 70:147-53
Manda, Hortance; Gouagna, Louis C; Foster, Woodbridge A et al. (2007) Effect of discriminative plant-sugar feeding on the survival and fecundity of Anopheles gambiae. Malar J 6:113

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