The Molecular and Cellular Immunology Core: The Emory Transplant Center and this Consortium benefits from an integrated approach to performing nonhuman primate (NHP) transplant tolerance research. The hub of this integration is the integrated Molecular and Cellular Immunology Core (MClC), which coordinates and streamlines all common assays and procedures, as well as the NHP procurement and typing needs for all members of the ETC. The MClC is comprised of five interacting elements: (1) The MHC Immunogenetics and Typing Core. (2) The Flow Cytometry Core. (3) The NHP Histopathology Core. (4) The Molecular Immunology and Virology Core and (5) The Functional Protective Immunity Core. Each Core addresses a critical need for the conduct of the complex experiments that are proposed in each of the projects and promotes collaboration between investigators. As such, the development of these integrated services has significantly increased the efficiency and the rigor with which our group is able to execute complex NHP transplantation tolerance research.

Public Health Relevance

Renal transplantation represents first-line therapy for patients with end-stage renal disease, with over 16,000 transplants being performed each year. While most patients initially do well post-transplant, they almost invariably face significant toxicities, including off-target complications of non-specific immunosuppression and the constant risk of chronic rejection. The ultimate answer for all of these issues is immune tolerance induction. This application seeks to define clinically-relevant tolerance-induction strategies, which could improve the lives of tens of thousands of transplant patients each year.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI051731-13
Application #
8705988
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Mathews, David V; Dong, Ying; Higginbotham, Laura B et al. (2018) CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection. J Clin Invest 128:4557-4572
Kean, Leslie S (2018) Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis. Blood 131:2630-2639
Colonna, Lucrezia; Peterson, Christopher W; Schell, John B et al. (2018) Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation. Nat Commun 9:4438
Song, M; Mulvihill, M S; Williams, K D et al. (2018) Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque. J Med Primatol 47:81-84
Taraseviciute, Agne; Tkachev, Victor; Ponce, Rafael et al. (2018) Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates. Cancer Discov 8:750-763
Ezekian, Brian; Schroder, Paul M; Freischlag, Kyle et al. (2018) Contemporary Strategies and Barriers to Transplantation Tolerance. Transplantation 102:1213-1222
Kean, Leslie S; Turka, Laurence A; Blazar, Bruce R (2017) Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev 276:192-212
Kwun, Jean; Manook, Miriam; Page, Eugenia et al. (2017) Crosstalk Between T and B Cells in the Germinal Center After Transplantation. Transplantation 101:704-712
Mathews, D V; Wakwe, W C; Kim, S C et al. (2017) Belatacept-Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells. Am J Transplant 17:2285-2299
Manook, M; Kwun, J; Burghuber, C et al. (2017) Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation. Am J Transplant 17:2055-2064

Showing the most recent 10 out of 73 publications