With largest population (1.3 billion), relative low infection rate (less than 0.05%) of human immunodeficiency virus (HIV) and rapid spread of HIV and sexually transmitted diseases (STDs), and well-developed infrastructure, China provides a unique opportunity to combat AIDS epidemic. Successful control of HIV/AIDS epidemic in China will contribute to control the epidemic in the world. We propose China's Integrated Programs for Research on AIDS (China- CIPRA). The overall goal of CIPRA is to strengthen the existing HIV/AIDS research infrastructure in China and build the capacity to conduct multi-disciplinary research to explore promising strategies for HIV/AIDS prevention, treatment, and control. To achieve this aim, China-CIPRA proposes 5 research projects and 4 supporting cores in its overall structure. The 5 projects and 4 cores are: Project 1 Epidemiology; Project 2 Behavioral Intervention; Project 3 Virology and Immunology; Project 4 Clinical Research; Project 5 Vaccine Development; Core Training; Core Data Management and Statistics; Core Central Laboratory; and Core Primate Research. As much as possible, the 5 projects and 4 cores are integrated to reduce duplication within and existing projects in China and increase efficiency in the studies being carried out. Project 1 will study HIV prevalence, incidence and risk factors by setting up 4 cohorts (former plasma donors-FPDs, injecting drug users-IDUs, female sex workers-FSWs and minority ethnic groups) in Shanxi, Yunnan and Xinjiang and following them up. Project 2 will launch theory-based intervention among HIV+ FPDs and IDUs identified in Project 1 to reduce HIV transmission from infected core groups to others. Project 3 will examine viral and host factors that correlate with transmission of infection and disease progression in FPDs, IDUs, and discordant couple (DC) from CIPRA as well as from HPTN. Project 4 will characterize the clinical manifestation of patients with HIV and develop standard of care based on Chinese settings. Project 5 will construct three classes of HIV-1 vaccine candidates based the NTV, Gdalt and rDNA vectors using HIV-1 antigens of Chinese origin will fully support the implementation of five projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI051915-03
Application #
6803148
Study Section
Special Emphasis Panel (ZAI1-DET-A (J1))
Program Officer
Hoff, Rodney
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
3
Fiscal Year
2004
Total Cost
$2,955,968
Indirect Cost
Name
National Center/AIDS/Std Control/Prevent
Department
Type
DUNS #
545274532
City
Beijing
State
Country
China
Zip Code
10220-6
Li, Yu; Chang, Zhaorui; Wu, Peng et al. (2018) Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010-2016. Emerg Infect Dis 24:1902-1906
Zhao, Min; Chen, Junbo; Tan, Shuguang et al. (2018) Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infection. J Virol 92:
Yang, Juan; Lau, Yiu Chung; Wu, Peng et al. (2018) Variation in Influenza B Virus Epidemiology by Lineage, China. Emerg Infect Dis 24:1536-1540
Artois, Jean; Jiang, Hui; Wang, Xiling et al. (2018) Changing Geographic Patterns and Risk Factors for Avian Influenza A(H7N9) Infections in Humans, China. Emerg Infect Dis 24:87-94
Virlogeux, Victor; Feng, Luzhao; Tsang, Tim K et al. (2018) Evaluation of animal-to-human and human-to-human transmission of influenza A (H7N9) virus in China, 2013-15. Sci Rep 8:552
Sun, Ruo-Xi; Lai, Sheng-Jie; Yang, Yang et al. (2017) Mapping the distribution of tick-borne encephalitis in mainland China. Ticks Tick Borne Dis 8:631-639
Lai, Shengjie; Li, Zhongjie; Wardrop, Nicola A et al. (2017) Malaria in China, 2011-2015: an observational study. Bull World Health Organ 95:564-573
Lai, Shengjie; Zhou, Hang; Xiong, Weiyi et al. (2017) Changing Epidemiology of Human Brucellosis, China, 1955-2014. Emerg Infect Dis 23:184-194
Wang, Xiling; Jiang, Hui; Wu, Peng et al. (2017) Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series. Lancet Infect Dis 17:822-832
Virlogeux, Victor; Yang, Juan; Fang, Vicky J et al. (2016) Association between the Severity of Influenza A(H7N9) Virus Infections and Length of the Incubation Period. PLoS One 11:e0148506

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