The continuing mission of the RadCCORE Biostatistics Core is to provide applied and theoretical biostatistics and bioinformatics expertise in support of the continued scientific mission of this grant. To this end, the core will serve as a centralized resource for expertise in applied and theoretical cancer biostatistics as well as data and scientific computing. The core faculty and staff will bring to bear not only technical expertise but also their vast experience in and passion for basic, clinical and translational cancer research to help to drive the science. The core personnel will be involved in every facet of the proposed research starting from the conception stage of studies and experiments through the interpretation and dissemination of the resulting findings. The core personnel will collaborate pro-actively with clinical and lab personnel of this project to ensure that studies and experiments are set up and executed optimally. The scope of scientific discovery and rigor should neither be limited nor compromised due to lack of appropriate and adequate statistical methodology or computational tools. When needed and appropriate, the core personnel will extend existing methods or develop novel statistical methods or computational tools to enable the investigators of this project address scientific questions with rigor and efficiency. The core will also provide ongoing education in the area of statistical methodology and concept to the project investigators.
Biostatisticians of this core collaborate with the investigators to produce well-designed studies and experiments with clearly defined objectives optimized to address the scientific questions in clinical and translational cancer research and ensure that the resulting data are analyzed rigorously and interpreted appropriately. They provide analysis support of both prospective and retrospective clinical data, and analysis support of both candidate and high throughput genomic data. When existing methods and tools are inadequate to address the scientific questions asked, the biostatisticians will develop requisite methods and tools.
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