The Pilots Project Program of the University of Pittsburgh CMCR manages pilot project applications by a highly efficient three-tiered approach. The ultimate goal is to encourage new investigators to enter the field of radiation biology for drug development of radiation mitigators. Drs. Louis Falo, Detcho Stoyanovsky, JIan Yu, and Tao Cheng all obtained new ROI grants based on collaboration with pilot project awardees (Table 1) or education and development core funding (Table 2-3). Recruited and solicited pilot project applications, as well as those coming through the UPCI-CMCR website were initially screened in a telephone conversation with Dr. Greenberger. Some applicants were appropriately discouraged from taking the time necessary to submit a full application, through this telephone conversation in which it was learned that goal of proposed pilot project was Inconsistent with the goals ofthe CMCR Program. This first tier telephone screening technique was appreciated by the applicants In that Dr. Greenberger could direct them to another potential source of pilot project funding for a clinical radiotherapy related project, such as the Pilot Project Program ofthe University of Pittsburgh Cancer Institute SPORE Program In Lung Cancer or SPORE Program in Head and Neck Cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI068021-06
Application #
8010803
Study Section
Special Emphasis Panel (ZAI1-KS-I (M1))
Project Start
2010-09-01
Project End
2015-08-31
Budget Start
2010-07-01
Budget End
2011-08-31
Support Year
6
Fiscal Year
2010
Total Cost
$414,594
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Tyurina, Yulia Y; Shrivastava, Indira; Tyurin, Vladimir A et al. (2018) ""Only a Life Lived for Others Is Worth Living"": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions. Antioxid Redox Signal 29:1333-1358
Schlattner, Uwe; Tokarska-Schlattner, Malgorzata; Epand, Richard M et al. (2018) NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy. Lab Invest 98:228-232
Willis, John; Epperly, Michael W; Fisher, Renee et al. (2018) Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiat Res 189:560-578
Leibowitz, Brian J; Yang, Liheng; Wei, Liang et al. (2018) Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med 10:
Knickelbein, Kyle; Tong, Jingshan; Chen, Dongshi et al. (2018) Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer. Oncogene 37:4599-4610
Wei, Liang; Leibowitz, Brian J; Epperly, Michael et al. (2018) The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice. Sci Rep 8:2072
Christner, Susan; Guo, Jianxia; Parise, Robert A et al. (2018) Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. J Pharm Biomed Anal 150:169-175
Wang, Yi-Jun; Fletcher, Rochelle; Yu, Jian et al. (2018) Immunogenic effects of chemotherapy-induced tumor cell death. Genes Dis 5:194-203
Chen, Dongshi; Tong, Jingshan; Yang, Liheng et al. (2018) PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A 115:3930-3935
Chen, Dongshi; Ni, Hong-Min; Wang, Lei et al. (2018) PUMA induction mediates acetaminophen-induced necrosis and liver injury. Hepatology :

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