Abstract

This Core establishes a focus and direction for the AADCRC program and provides for general administrative support of AADCRC activities. The Core leadership was therefore developed to include individuals with extensive experience in basic and clinical research studies of asthma and to represent expertise in both airway epithelial cell biology and innate immunity. In addition, the Core orchestrates oversight of the AADCRC by an Internal Advisory Committee and ad hoc consultants. The Core also includes a Divisional Adminstrator/Financial Manager and a Research Administator to assist Projects and Cores in a variety of administrative tasks. These include preparation and oversight of budgets, human and animal use approvals, progress reports, and manuscripts as well as arrangements for professional travel and needs for human resources. The Core also incorporates a Network Manager/Computer Systems Analyst who provides for computer and electronic support of all AADCRC personnel and a Lab Assistant for support of general and shared lab tasks.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI070489-08
Application #
8508649
Study Section
Special Emphasis Panel (ZAI1-PA-I)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
8
Fiscal Year
2013
Total Cost
$113,071
Indirect Cost
$38,553

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Keeler, Shamus P; Agapov, Eugene V; Hinojosa, Michael E et al. (2018) Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants. J Immunol 201:2354-2368
Myung, Jihwan; Schmal, Christoph; Hong, Sungho et al. (2018) The choroid plexus is an important circadian clock component. Nat Commun 9:1062
Li, Shuai; O'Neill, Sofia R S; Zhang, Yong et al. (2017) Estrogen receptor ? is required for oviductal transport of embryos. FASEB J 31:1595-1607
Benedetto, Roberta; Ousingsawat, Jiraporn; Wanitchakool, Podchanart et al. (2017) Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep 7:12397
Liu, Yongjian; Gunsten, Sean P; Sultan, Deborah H et al. (2017) PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation. Radiology 283:758-768
Steed, Ashley L; Christophi, George P; Kaiko, Gerard E et al. (2017) The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science 357:498-502
Woodruff, Prescott G; van den Berge, Maarten; Boucher, Richard C et al. (2017) American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report. Am J Respir Crit Care Med 196:375-381
Chatterjee, Srirupa; Luthra, Priya; Esaulova, Ekaterina et al. (2017) Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nat Microbiol 2:17101
Olias, Philipp; Etheridge, Ronald D; Zhang, Yong et al. (2016) Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-?-Dependent Gene Expression. Cell Host Microbe 20:72-82
Stier, Matthew T; Bloodworth, Melissa H; Toki, Shinji et al. (2016) Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. J Allergy Clin Immunol 138:814-824.e11

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