Abstract

The goals of the Administrative Core are to provide administrative support and structure for the multi-projectgrant program projects. Specifically, the Administrative Core will 1) provide administrative oversight for thescientific conduct of each of the projects, ensuring that overlap does not occur in the individual projects; 2)provide administrative oversight related to the budgetary interactions between the University of Pittsburgh,Rutgers University and Millenia Hope Inc.; 3) interact with NIH program staff relating to the goals of this U19multi-project cooperative grant program for the preclinical development of ribonuclease H inhibitors; 4) plan,schedule and coordinate the annual meeting of the Scientific Steering Committee comprised of keypersonnel from the program project grant, Scientific Advisory Panel members, and NIAID/NIMH ScientificCoordinators; and 5) plan, schedule and conduct monthly teleconferences among the Project Leaders andkey personnel.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI073975-01
Application #
7257664
Study Section
Special Emphasis Panel (ZAI1-TP-A (J1))
Project Start
2007-01-01
Project End
2012-02-29
Budget Start
2007-01-01
Budget End
2008-02-29
Support Year
1
Fiscal Year
2007
Total Cost
$74,372
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Himmel, Daniel M; Myshakina, Nataliya S; Ilina, Tatiana et al. (2014) Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs. J Mol Biol 426:2617-31
Kirby, Karen A; Marchand, Bruno; Ong, Yee Tsuey et al. (2012) Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase. Antimicrob Agents Chemother 56:2048-61
Ilina, Tatiana; Labarge, Krystal; Sarafianos, Stefan G et al. (2012) Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity. Biology (Basel) 1:521-41
Christen, Martin T; Menon, Lakshmi; Myshakina, Nataliya S et al. (2012) Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain. Chem Biol Drug Des 80:706-16
Gong, Qingguo; Menon, Lakshmi; Ilina, Tatiana et al. (2011) Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor. Chem Biol Drug Des 77:39-47
Davis, Caroline A; Parniak, Michael A; Hughes, Stephen H (2011) The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC. Virology 419:64-71
Felts, Anthony K; Labarge, Krystal; Bauman, Joseph D et al. (2011) Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. J Chem Inf Model 51:1986-98
Abram, Michael E; Sarafianos, Stefan G; Parniak, Michael A (2010) The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site. Retrovirology 7:6
Sarafianos, Stefan G; Marchand, Bruno; Das, Kalyan et al. (2009) Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J Mol Biol 385:693-713