The overall purpose of the Biological Informafics Core (BIC) is to provide bidnformafics and biostafisfical support to projects 1 to 3. The core will leverage its major computafional and human infrastructure at the University of Maryland School of Medicine, Institute for Genome Sciences (IGS), to perform 1) Chlamydia trachomatis and Chlamydia caviae genomic based analyses, such as genome sequence assemblies, de novo annotation/remapping and genome sequences comparative analyses, 2) metagenomic analyses of metatranscriptomic data such as transcripts assemblies, functional annotafion, comparative funcfional analyses, phylogenomic analyses of the transcripts, and community metabolic pathways reconstrucfion;3) model-based statistical analyses of community composition in relation to the metadata collected in each project;4) develop a web-based resource for the distribution, access, browsing, querying and analysis of the data generated by each of the three projects 1-3. The Biological Informatics Core will work in close cdlaborafion with Dr. Abdo, at the University of Idaho who will be responsible for the stafisfical analysis, while Dr. White will lead the remaining acfivifies at IGS. The team assembled for this project comprises of experienced bioinformaficists and scienfists, who were at the onset of the genomic revdufion while at the Institute for Genomic Research in the 1990s. Their high level of expertise and commitment to serve the research scientific community with open-access to data and software will be key in making sure that the data and findings of the projects the Biological Informafics Core will support will have maximum impact on the chlamydial and STI clinical and research community.

Public Health Relevance

Chlamydial infecfion are a major health risk to young sexually acfive women and can results in serious condifions such as pelvic infiammatory disease (PID) a cause of infertility in women. Studies on Chlamydial Infecfions have focused on the pathogen itself. It is becoming increasingly evident that the microbes that inhabit the vagina play a critical protecfive role. We will examine how the vaginal microbiota reacts to Chlamydial infecfions and treatments in order to provide a new view of the infecfious

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI084044-01
Application #
7762450
Study Section
Special Emphasis Panel (ZAI1-MMT-M (M1))
Project Start
2009-09-21
Project End
2014-08-31
Budget Start
2009-09-21
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$430,549
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Palmer, Allison; Criss, Alison K (2018) Gonococcal Defenses against Antimicrobial Activities of Neutrophils. Trends Microbiol 26:1022-1034
Schroeder, Holly A; Nunn, Kenetta L; Schaefer, Alison et al. (2018) Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition. Mucosal Immunol 11:1477-1486
Ragland, Stephanie A; Humbert, Mar?a V; Christodoulides, Myron et al. (2018) Neisseria gonorrhoeae employs two protein inhibitors to evade killing by human lysozyme. PLoS Pathog 14:e1007080
van Houdt, Robin; Ma, Bing; Bruisten, Sylvia M et al. (2018) Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: a case-control study. Sex Transm Infect 94:117-123
Cornejo, Omar E; Hickey, Roxana J; Suzuki, Haruo et al. (2018) Focusing the diversity of Gardnerella vaginalis through the lens of ecotypes. Evol Appl 11:312-324
Tyssen, David; Wang, Ying-Ying; Hayward, Joshua A et al. (2018) Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid. mSphere 3:
Tachedjian, Gilda; O'Hanlon, Deirdre E; Ravel, Jacques (2018) The implausible ""in vivo"" role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota. Microbiome 6:29
Noyes, Noelle; Cho, Kyu-Chul; Ravel, Jacques et al. (2018) Associations between sexual habits, menstrual hygiene practices, demographics and the vaginal microbiome as revealed by Bayesian network analysis. PLoS One 13:e0191625
Wang, Liuyang; Pittman, Kelly J; Barker, Jeffrey R et al. (2018) An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease. Cell Host Microbe 24:308-323.e6
Bavoil, Patrik M; Marques, Patricia X; Brotman, Rebecca et al. (2017) Does Active Oral Sex Contribute to Female Infertility? J Infect Dis 216:932-935

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