Abstract

The Administrative Core will develop and implement a management plan to ensure the success of the U19 program. This Core will continuously monitor the scientific progress of each component of the program. The Core will facilitate the seamless integration of the members of the consortium. The Core will also facilitate communications with the NIH and with the larger research community. The Core will manage financial resources, ensure that intellectual property issues are respected, and initiate all external collaborations. The educational component of the Core will ensure that the advances made in the program will catalyze innovation in the larger scientific community. Specifically, the Core will offer Phospho-Flow/CyTOF and Systems Immunology courses that will provide the external research community with enhanced hands-on experience and knowledge of systems biology approaches and their applications to the study the immune system.

Public Health Relevance

The Administrative Core will manage the scientific interactions and financial resources of the project and will conduct training course to disseminate methods and techniques developed in this program to other scientists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI100627-03
Application #
8717578
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Anchang, Benedict; Davis, Kara L; Fienberg, Harris G et al. (2018) DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. Proc Natl Acad Sci U S A 115:E4294-E4303
Good, Zinaida; Sarno, Jolanda; Jager, Astraea et al. (2018) Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse. Nat Med 24:474-483
McAlpine, William; Sun, Lei; Wang, Kuan-Wen et al. (2018) Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. Proc Natl Acad Sci U S A 115:E11523-E11531
Morin, Matthew D; Wang, Ying; Jones, Brian T et al. (2018) Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. J Am Chem Soc 140:14440-14454
Johnson, Jarrod S; Lucas, Sasha Y; Amon, Lynn M et al. (2018) Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host Microbe 23:366-381.e9
Goltsev, Yury; Samusik, Nikolay; Kennedy-Darling, Julia et al. (2018) Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging. Cell 174:968-981.e15
Wagle, Mayura V; Marchingo, Julia M; Howitt, Jason et al. (2018) The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen. Cell Rep 24:577-584
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara et al. (2018) Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database. Nat Commun 9:441
Zhang, Duanwu; Tomisato, Wataru; Su, Lijing et al. (2017) Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. Proc Natl Acad Sci U S A 114:E5197-E5206
Sun, Lei; Jiang, Zhengfan; Acosta-Rodriguez, Victoria A et al. (2017) HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med 214:3263-3277

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