TheproposedAdministrativeCore(CoreA)willinteractcloselywilleachoftheproposed4projectsandthe twootherproposedcores:theScientificCoreandtheDataManagementandAnalysisCore.Wehave developedadetailedplantostrivetooptimizethesynergyandinteractionsamongtheprojects,coresand personnelinvolvedinthestudiesproposedinthisU19renewalapplication.Suchinteractionswillbefacilitated bytheexistence,atStanford,ofresourcessuchastheHumanImmuneMonitoringCore(HIMC),inwhichthe workinScientificCorewillbeconductedandwhosedirector,HoldenMaecker,isalsothedirectorofour proposedScientificCore.OtherresourcesavailabletothisU19includetheSeanN.ParkerCenterforAllergy andAsthmaResearch,whichisdirectedbyDr.KariNadeau,whoistheProject3Lead,andtheClinicaland TranslationalResearchUnit(CTRU),whichisdirectedbytheProject1Lead,Dr.SharonChinthrajah.Notably, themembersoftheStanfordteamarealreadyinteractingscientificallyunderthecurrentAADCRCU19 program.Accordingly,shouldthisrenewalapplicationbefunded,theproposedworktoadvanceour understandingofthepathologyoffoodallergy,andthemechanismsthatcontributetodesensitizationand toleranceinthisdisorder,willrepresentacontinuationandsubstantialexpansionoftheseongoing collaborativeefforts. TheAdministrativeCorehastwoSpecificAims:
Aim1 :ProvidescientificadministrationandcoordinationinsupportoftheobjectivesoftheStanfordAADCRC;? Aim2:Providefiscaloversightandadministration. AspecialfeatureofAim1isthatDr.MarkDavis,directoroftheStanfordInstituteforImmunology, Transplantation,&Infection(ITI),willco-chair,alongwiththePIoftheapplication,theScientificAdvisory BoardforthisU19,providingthegroupwiththeexpertisehehasacquiredinmanyotherhumanimmune monitoringprojectsbeingpursuedwiththeassistanceoftheHIMC(thatishousedinITI).TheScientific AdvisoryBoardalsowillincludeDr.BaliPulendran,arenownedsystemsimmunologist,andDr.AndyFire,a notedmolecularbiologistwhoalsowillbeaCo-InvestigatorinProject2.
| Hartmann, Felix J; Simonds, Erin F; Bendall, Sean C (2018) A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. Sci Rep 8:10770 |
| Klein, Ofir; Roded, Amit; Hirschberg, Koret et al. (2018) Imaging FITC-dextran as a Reporter for Regulated Exocytosis. J Vis Exp : |
| Zhang, Wenming; Lin, Chunrong; Sampath, Vanitha et al. (2018) Impact of allergen immunotherapy in allergic asthma. Immunotherapy 10:579-593 |
| Sampath, Vanitha; Sindher, Sayantani B; Zhang, Wenming et al. (2018) New treatment directions in food allergy. Ann Allergy Asthma Immunol 120:254-262 |
| Sindher, Sayantani B; Long, Andrew; Acharya, Swati et al. (2018) The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses. Clin Rev Allergy Immunol 55:190-204 |
| Mukai, Kaori; Tsai, Mindy; Saito, Hirohisa et al. (2018) Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev 282:121-150 |
| Keren, Leeat; Bosse, Marc; Marquez, Diana et al. (2018) A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging. Cell 174:1373-1387.e19 |
| Chinthrajah, R Sharon; Purington, Natasha; Andorf, Sandra et al. (2018) Development of a tool predicting severity of allergic reaction during peanut challenge. Ann Allergy Asthma Immunol 121:69-76.e2 |
| Andorf, Sandra; Purington, Natasha; Block, Whitney M et al. (2018) Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial. Lancet Gastroenterol Hepatol 3:85-94 |
| Tsai, Cheng-Ting; Mukai, Kaori; Robinson, Peter V et al. (2018) Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE. J Allergy Clin Immunol 141:1901-1904.e15 |
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