The administrative core will provide a management plan to coordinate the whole FLUOMICS consortium by 1) the establishment of an organizational structure centered around an Executive Committee responsible for monitoring overall program progress, implementing a Pilot Research Program, and making decisions on staffing plans, allocation of resources, scientific core usage and other policies; 2) the coordination of conference calls and of annual meetings between the Pis, selected key personnel, the Steering Committee and NIAID; 3) assisting the members of this consortium in reagents and data sharing, manuscript preparations, public release of data and submission of annual progress reports to the NIH; and 4) providing training opportunities in Systems Biology for the infection disease scientist. The Core Director has expertise in the coordination of program projects and big consortiums, as he is the Director of one of the NIAID Centers of Excellence of Influenza Research and Surveillance. This FLUOMICS proposal complements and does not overlap with the Center of Excellence, as the influenza center does not include the use of a systems biology approach in its research agenda. The Core Co-Director is in charge ofthe training program to be implemented in years 2 to 5 and he has past experience in organizing training for students in systems biology approaches.
We are planning to create an innovative discovery platform integrating global scale OMICS and systems biology approaches to identify novel host genes and immune networks that impact susceptibility to influenza virus infection. This will be done through an intercollaborative multidisciplinary approach involving 3 scientific projects, 3 -OMICS cores, a Modeling Core, a Virus Core, a Data Management and Resources Dissemination Core and 8 different institutions. The administrative will take care of coordinating such a complex organization to assure maximal research progress, and organize a training symposia in systems biology.
| Zhao, Nan; Sebastiano, Vittorio; Moshkina, Natasha et al. (2018) Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol 25:885-893 |
| White, Kris M; Abreu Jr, Pablo; Wang, Hui et al. (2018) Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis 4:146-157 |
| Dornfeld, Dominik; Dudek, Alexandra H; Vausselin, Thibaut et al. (2018) Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8:7782 |
| Zhang, Liang; Wang, Juan; Muñoz-Moreno, Raquel et al. (2018) Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting. J Virol : |
| Hancock, Aidan S; Stairiker, Christopher J; Boesteanu, Alina C et al. (2018) Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation. J Virol 92: |
| Dornfeld, Dominik; Dudek, Alexandra H; Vausselin, Thibaut et al. (2018) SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8:2092 |
| Heinz, Sven; Texari, Lorane; Hayes, Michael G B et al. (2018) Transcription Elongation Can Affect Genome 3D Structure. Cell 174:1522-1536.e22 |
| Pohl, Marie O; von Recum-Knepper, Jessica; Rodriguez-Frandsen, Ariel et al. (2017) Identification of Polo-like kinases as potential novel drug targets for influenza A virus. Sci Rep 7:8629 |
| Martín-Vicente, María; Medrano, Luz M; Resino, Salvador et al. (2017) TRIM25 in the Regulation of the Antiviral Innate Immunity. Front Immunol 8:1187 |
| García-Sastre, Adolfo (2017) Ten Strategies of Interferon Evasion by Viruses. Cell Host Microbe 22:176-184 |
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