The Data Management and Resource Dissemination Core (DMRDC) will: a) provide the infrastructure to aid hypothesis generation, b) integrate public and private databases, c) store results of bioinformatic analyses, d) store and organize experimental functional and biochemical data, e) facilitate material and project management, f) enable seamless interaction between the administrative core, technology core and the research projects, and g) provide a public data access gateway. This Core is committed to providing the scientific community a query interface to all information derived from bioinformatics analyses, experimental functional and biochemical experiments on pathogens and purified gene products, and biological and biochemical reagents. Our NIAID project will generate a large amount of data during the 5-year award term. The efficient management of these data is crucial for the success of the proposed work. Publicly available resources will be utilized in order to reduce redundancies in efforts. In return, the resources generated by this program will be made available in a form that enables simple integration into other resources. Data release into the public domain will be governed by the Administrative core and will adhere to NIAID/NIH policies.

Public Health Relevance

Large collaborative projects have the potential to outperform a group of smaller research projects with similar scope and size. This synergy can be realized only when experimental data, resources, and information are shared efficiently across the performance sites. This proposal aims to generate the informatics framework to bring this synergy to fruition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI107792-05
Application #
9314375
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Herrou, Julien; Willett, Jonathan W; Fiebig, Aretha et al. (2018) Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus. Mol Microbiol :
Tien, Matthew; Fiebig, Aretha; Crosson, Sean (2018) Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival. Elife 7:
Herrou, Julien; Czy?, Daniel M; Fiebig, Aretha et al. (2018) Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor. J Biol Chem 293:7437-7456
Czy?, Daniel M; Willett, Jonathan W; Crosson, Sean (2017) Brucella abortus Induces a Warburg Shift in Host Metabolism That Is Linked to Enhanced Intracellular Survival of the Pathogen. J Bacteriol 199:
Mitchell, Anthony; Tam, Christina; Elli, Derek et al. (2017) Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis. MBio 8:
Herrou, Julien; Willett, Jonathan W; Czy?, Daniel M et al. (2017) Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria. J Bacteriol 199:
Baric, Ralph S; Crosson, Sean; Damania, Blossom et al. (2016) Next-Generation High-Throughput Functional Annotation of Microbial Genomes. MBio 7:
Czy?, Daniel M; Jain-Gupta, Neeta; Shuman, Howard A et al. (2016) A dual-targeting approach to inhibit Brucella abortus replication in human cells. Sci Rep 6:35835
Willett, Jonathan W; Herrou, Julien; Czyz, Daniel M et al. (2016) Brucella abortus ?rpoE1 confers protective immunity against wild type challenge in a mouse model of brucellosis. Vaccine 34:5073-5081
Herrou, Julien; Czy?, Daniel M; Willett, Jonathan W et al. (2016) WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System. J Bacteriol 198:1281-93

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