The Discovery and Translational Services will provide commonly needed services that require specialized equipment and capabilities that are not generally available in a typical microbiological research laboratory, additional expertise to investigators in fields outside their areas of specialization, access to research technologies not otherwise available and to translational and product development capabilities These services will include both services provided by core staff and services provided on a fee-for-service basis. The core will make use of a management structure that encourages productive and creative collaboration and allows integration and coordination between research project investigators and core scientific staff. The specific services provided or made available include: ? biomolecule production ? small molecule screening ? medicinal chemistry ? discovery formulation ? assessment of compound toxicity
Individual investigators do not possess all ofthe expertise, equipment, and capabilities necessary to complete the discovery and translational objectives of the Center. This core will either provide needed research services directly or through fee for service relationships with other research service providers. The core will also be a source of translational expertise available to all Center investigators.
| Coulter, Michael E; Dorobantu, Cristina M; Lodewijk, Gerrald A et al. (2018) The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep 24:973-986.e8 |
| Lian, Wenlong; Jang, Jaebong; Potisopon, Supanee et al. (2018) Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein. ACS Infect Dis 4:1395-1406 |
| de Wispelaere, Melissanne; Lian, Wenlong; Potisopon, Supanee et al. (2018) Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chem Biol 25:1006-1016.e8 |
| Chao, Luke H; Jang, Jaebong; Johnson, Adam et al. (2018) How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion. Elife 7: |
| Pitts, Jared D; Li, Pi-Chun; de Wispelaere, Melissanne et al. (2017) Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus. Antiviral Res 147:124-130 |
| Salgado, Eric N; Upadhyayula, Srigokul; Harrison, Stephen C (2017) Single-particle detection of transcription following rotavirus entry. J Virol : |
| Raaben, Matthijs; Jae, Lucas T; Herbert, Andrew S et al. (2017) NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell Host Microbe 22:688-696.e5 |
| Wang, May K; Lim, Sun-Young; Lee, Soo Mi et al. (2017) Biochemical Basis for Increased Activity of Ebola Glycoprotein in the 2013-16 Epidemic. Cell Host Microbe 21:367-375 |
| Filippakis, Harilaos; Alesi, Nicola; Ogorek, Barbara et al. (2017) Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R. Oncotarget 8:38099-38112 |
| Chou, Yi-Ying; Cuevas, Christian; Carocci, Margot et al. (2016) Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol 90:4494-4510 |
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