Abstract

The Center for Research in Diagnostics and Discovery consists of five research projects, an Administrative Core and a Translational Core. The Administrative Core oversees regulatory compliance relating to Human Subjects, Vertebrate Animals, Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), Recombinant DNA, Biosafety in Microbiology and Biochemical Laboratories Guidelines, Select Agents, Conflict of Interest, NIH Open Access Policy as well as Intellectual Property, and provides fiscal management of the award. The Administrative Core works in conjunction with the Scientific Advisory Committee, consisting of the research project leaders (Ralph Baric, Michael Katze, W. lan Lipkin, David Relman, Kenneth Shepard), director of the Translational Core (William Karesh), and three external members (Roy Curtiss, Claire Fraser-Liggett, Richard Whitley), to track progress toward achieving milestones, review and approve supplementary research projects, and make decisions regarding resource allocation.

Public Health Relevance

The Administrative Core provides an organizational structure for the management of the Center for Research in Diagnostics and Discovery and ensures that the investigators are in regulatory and fiscal compliance with federal, state, local and institutional authorities, and that they meet objectives of the award.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI109761-03
Application #
9010921
Study Section
Special Emphasis Panel (ZAI1-LR-M)
Project Start
Project End
Budget Start
2016-03-01
Budget End
2017-02-28
Support Year
3
Fiscal Year
2016
Total Cost
$276,328
Indirect Cost
$103,623

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Cockrell, Adam S; Johnson, Joshua C; Moore, Ian N et al. (2018) A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques. Sci Rep 8:10727
Lindesmith, Lisa C; Brewer-Jensen, Paul D; Mallory, Michael L et al. (2018) Antigenic Characterization of a Novel Recombinant GII.P16-GII.4 Sydney Norovirus Strain With Minor Sequence Variation Leading to Antibody Escape. J Infect Dis 217:1145-1152
Allicock, Orchid M; Guo, Cheng; Uhlemann, Anne-Catrin et al. (2018) BacCapSeq: a Platform for Diagnosis and Characterization of Bacterial Infections. MBio 9:
Williams, Simon H; Che, Xiaoyu; Garcia, Joel A et al. (2018) Viral Diversity of House Mice in New York City. MBio 9:
Gralinski, Lisa E; Sheahan, Timothy P; Morrison, Thomas E et al. (2018) Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. MBio 9:
Williams, Simon H; Cordey, Samuel; Bhuva, Nishit et al. (2018) Investigation of the Plasma Virome from Cases of Unexplained Febrile Illness in Tanzania from 2013 to 2014: a Comparative Analysis between Unbiased and VirCapSeq-VERT High-Throughput Sequencing Approaches. mSphere 3:
Williams, Simon H; Che, Xiaoyu; Paulick, Ashley et al. (2018) New York City House Mice (Mus musculus) as Potential Reservoirs for Pathogenic Bacteria and Antimicrobial Resistance Determinants. MBio 9:
Nagy-Szakal, Dorottya; Barupal, Dinesh K; Lee, Bohyun et al. (2018) Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Sci Rep 8:10056
Kocher, Jacob F; Lindesmith, Lisa C; Debbink, Kari et al. (2018) Bat Caliciviruses and Human Noroviruses Are Antigenically Similar and Have Overlapping Histo-Blood Group Antigen Binding Profiles. MBio 9:
Agnihothram, Sudhakar; Menachery, Vineet D; Yount Jr, Boyd L et al. (2018) Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform. J Virol 92:

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