High quality clinical and epidemiologic research on tuberculosis requires well-run field sites in high burden TB settings that can recruit and retain TB patients, exposed contacts and controls; ensure secure and complete data collection and management; ensure that participant receive high quality appropriate clinical care; conduct appropriate laboratory testing and interact constructively with local clinics and National TB programs. Over the past 4 years, a Harvard- Socios-en-Salud team has built a highly efficient and well-organized research infrastructure that has recruited and retained over 16000 participants.
The aim of the Core is to support the TBRU's scientific project by recruiting and following TB patient and household contact cohorts in Lima, Peru, obtaining relevant data and samples and ensuring the efficient transfer of data and samples to the Data Management Center in Boston To that end, we propose to identify and reconsent 3000 of our initial cohort members with well defined TB outcomes for human genotyping and to enroll 300 new TB cases and 350 of their household contacts who will be followed for relevant outcomes and who will provide blood and urine samples for transciptional profiling and biomarker assessment.

Public Health Relevance

The aim of this Human Subjects Core is to support the TBRU's scientific goals by recruiting and following TB patient and household contact cohorts in Lima, Peru, obtaining relevant data and samples and ensuring the efficient transfer of data and samples to the Data Management Center in Boston.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI111224-07
Application #
10089392
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2015-02-01
Project End
2022-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
7
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
James, Charlotte A; Yu, Krystle K Q; Gilleron, Martine et al. (2018) CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis. Cell Chem Biol 25:392-402.e14
Mizoguchi, Fumitaka; Slowikowski, Kamil; Wei, Kevin et al. (2018) Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nat Commun 9:789
Davenport, Emma E; Amariuta, Tiffany; Gutierrez-Arcelus, Maria et al. (2018) Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial. Genome Biol 19:168
Carette, Xavier; Platig, John; Young, David C et al. (2018) Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface. MBio 9:
Lehmann, Johannes; Cheng, Tan-Yun; Aggarwal, Anup et al. (2018) An Antibacterial ?-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis. Angew Chem Int Ed Engl 57:348-353
Wun, Kwok S; Reijneveld, Josephine F; Cheng, Tan-Yun et al. (2018) T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nat Immunol 19:397-406
Madigan, Cressida A; Cambier, C J; Kelly-Scumpia, Kindra M et al. (2017) A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell 170:973-985.e10
Moody, D Branch (2017) How T cells grasp mycobacterial lipid antigens. Proc Natl Acad Sci U S A 114:13312-13314
Brennan, Patrick J; Cheng, Tan-Yun; Pellicci, Daniel G et al. (2017) Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface. Proc Natl Acad Sci U S A 114:8348-8353
Rao, Deepak A; Gurish, Michael F; Marshall, Jennifer L et al. (2017) Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature 542:110-114

Showing the most recent 10 out of 49 publications