The research proposed for the University of Michigan NAMSED Cooperative Research Center (CRC) involves the coordinated effort of microbiologists, immunologists, bioengineers, tissue engineers and epithelial biologists. The Administrative Core is responsible for ensuring integration of all aspects of the proposed work. In order to play a central role in coordinating, supervising and managing the basic science research efforts of the entire U of M NAMSED CRC, the following specific aims/missions are proposed for the Administrative Core; 1) To provide leadership for the overall administration, coordination, and management of the Center, 2) To foster productive and collaborative research between all investigators on all projects, 3) To facilitate and coordinate data sharing/analysis and communications for all Center-supported projects, 4) To establish a well- planned structure for the administrative staff; to ensure proper training and experience is in place, 5) To oversee the fiscal management of all Center activities, 6) To interface with the ERIN Network Committee and other outside scientific and medical stakeholders, and 7) To manage and oversee the Research Pilot Projects Plan. An administrative structure has been established that will allow the effective completion of these specific aims.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI116482-03
Application #
9240578
Study Section
Special Emphasis Panel (ZAI1-LG-M)
Project Start
Project End
Budget Start
2017-03-01
Budget End
2018-02-28
Support Year
3
Fiscal Year
2017
Total Cost
$106,062
Indirect Cost
$26,325
Name
University of Michigan Ann Arbor
Department
Type
Domestic Higher Education
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Cruz-Acuña, Ricardo; Quirós, Miguel; Huang, Sha et al. (2018) Publisher Correction: PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc :
Mirabelli, Carmen; Wobus, Christiane E (2018) All Aboard! Enteric Viruses Travel Together. Cell Host Microbe 24:183-185
Mertz, David R; Ahmed, Tasdiq; Takayama, Shuichi (2018) Engineering cell heterogeneity into organs-on-a-chip. Lab Chip 18:2378-2395
Han, Xu; Lee, Allen; Huang, Sha et al. (2018) Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Gut Microbes :1-18
Wobus, Christiane E (2018) The Dual Tropism of Noroviruses. J Virol 92:
Turula, Holly; Wobus, Christiane E (2018) The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity. Viruses 10:
Dame, Michael K; Attili, Durga; McClintock, Shannon D et al. (2018) Identification, isolation and characterization of human LGR5-positive colon adenoma cells. Development 145:
Tsai, Yu-Hwai; Czerwinski, Michael; Wu, Angeline et al. (2018) A Method for Cryogenic Preservation of Human Biopsy Specimens and Subsequent Organoid Culture. Cell Mol Gastroenterol Hepatol 6:218-222.e7
Spence, Jason R (2018) Taming the Wild West of Organoids, Enteroids, and Mini-Guts. Cell Mol Gastroenterol Hepatol 5:159-160
Quiros, Miguel; Nishio, Hikaru; Neumann, Philipp A et al. (2017) Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin Invest 127:3510-3520

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