Developing a broadly effective vaccine against HCV is one of the most important goals in HCV research. For this program focusing on understand antibody responses elicited in infection and vaccination and on applying the knowledge to designing HCV vaccine antigens, the Admin Core is responsible for overseeing and supporting the research activities to accomplish four broad areas: administrative and fiscal management, communication management, scientific oversight, and scientific outreach. The Admin Core will provide fiscal oversight, facilitate communication and reagent sharing between research labs, coordinate sample shipment and storage between the research sites, monitor scientific progress through internal reviews and the annual scientific advisory board meeting, coordinate travels of project PIs and researchers to present results in scientific symposiums and the annual NIH U19 meeting, assist U19 researchers in the preparation and submission of scientific publications, and organize the annual Scientific Advisory Committee meeting. The Admin Core will be led by the U19 Center Director with the help of an Admin Core Manager and an Admin Core Associate to accomplish the above tasks in a cost-effective manner.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI123861-01
Application #
9096639
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2016-04-01
Project End
2021-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Tzarum, Netanel; Wilson, Ian A; Law, Mansun (2018) The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein. Front Immunol 9:1315
Aleman, Fernando; Tzarum, Netanel; Kong, Leopold et al. (2018) Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proc Natl Acad Sci U S A 115:7569-7574
Velázquez-Moctezuma, Rodrigo; Galli, Andrea; Law, Mansun et al. (2018) Hepatitis C virus escape studies for human antibody AR3A reveals a high barrier to resistance and novel insights on viral antibody evasion mechanisms. J Virol :
Gopal, Radhika; Jackson, Kelli; Tzarum, Netanel et al. (2017) Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis. PLoS Pathog 13:e1006735
Velázquez-Moctezuma, Rodrigo; Law, Mansun; Bukh, Jens et al. (2017) Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A. PLoS Pathog 13:e1006214
Morris, Charles D; Azadnia, Parisa; de Val, Natalia et al. (2017) Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers. MBio 8:
Kong, Leopold; Lee, David E; Kadam, Rameshwar U et al. (2016) Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen. Proc Natl Acad Sci U S A 113:12768-12773