Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA067763-02
Application #
2111534
Study Section
Special Emphasis Panel (SRC (08))
Project Start
1995-09-08
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205
Hassan, Abdalla E A; Abou-Elkhair, Reham A I; Parker, William B et al. (2016) 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases. Bioorg Chem 65:9-16
Hassan, Abdalla E A; Abou-Elkhair, Reham A I; Riordan, James M et al. (2012) Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides. Eur J Med Chem 47:167-74
Kang, You-Na; Zhang, Yang; Allan, Paula W et al. (2010) Structure of grouper iridovirus purine nucleoside phosphorylase. Acta Crystallogr D Biol Crystallogr 66:155-62
Tai, C-K; Wang, W; Lai, Y-H et al. (2010) Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene. Cancer Gene Ther 17:614-23
Hassan, Abdalla E A; Parker, William B; Allan, Paula W et al. (2009) Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer. Nucleosides Nucleotides Nucleic Acids 28:642-56
Sorscher, E J; Harris, J; Alexander, M et al. (2006) Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening. Gene Ther 13:781-8
Dontsova, Maria V; Gabdoulkhakov, Azat G; Molchan, Olga K et al. (2005) Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state. Acta Crystallogr Sect F Struct Biol Cryst Commun 61:337-40
Silamkoti, A V; Allan, P W; Hassan, A E A et al. (2005) Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer. Nucleosides Nucleotides Nucleic Acids 24:881-5
Toms, Angela V; Wang, Weiru; Li, Yingbo et al. (2005) Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase. Acta Crystallogr D Biol Crystallogr 61:1449-58
Zang, Yang; Wang, Wen-Hu; Wu, Shaw-Wen et al. (2005) Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. J Biol Chem 280:22318-25

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