Abstract

The goal of this proposed research is to isolate novel anticancer agents produced by microorganisms (actinomycEtales, eubacteria and fungi) from the marine environment. This endeavor includes: l) Isolation of microorganisms from diverse marine environments, including those living in close association with marine animals and plants 2) Taxonomic identification of these microorganisms and cataloging by type and substrate specificity 3) Fermentation for production of bioactive compounds and to provide extracts for testing in CODS 4) Isolation and characterization of these active compounds

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19CA067786-02
Application #
5209445
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Dalisay, Doralyn S; Williams, David E; Wang, Xiao Ling et al. (2013) Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products. PLoS One 8:e77078
Prasad, Pritesh; Aalbersberg, William; Feussner, Klaus-D et al. (2011) Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp. Tetrahedron 67:8529-8531
Williams, David E; Loganzo, Frank; Whitney, Lauren et al. (2011) Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity. Pharm Biol 49:296-301
Janso, Jeffrey E; Carter, Guy T (2010) Biosynthetic potential of phylogenetically unique endophytic actinomycetes from tropical plants. Appl Environ Microbiol 76:4377-86
Williams, David E; Yu, Ker; Behrisch, Hans W et al. (2009) Rolloamides A and B, cytotoxic cyclic heptapeptides isolated from the Caribbean marine sponge Eurypon laughlini. J Nat Prod 72:1253-7
Williams, David E; Hollander, Irwin; Feldberg, Larry et al. (2009) Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens. J Nat Prod 72:1106-9
Whitson, Emily L; Bugni, Tim S; Chockalingam, Priya S et al. (2009) Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta. J Org Chem 74:5902-8
Roll, Deborah M; Barbieri, Laurel R; Bigelis, Ramunas et al. (2009) The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. J Nat Prod 72:1944-8
Whitson, Emily L; Ratnayake, Anokha S; Bugni, Tim S et al. (2009) Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp. J Org Chem 74:1156-62
Bugni, Tim S; Harper, Mary Kay; McCulloch, Malcolm W B et al. (2008) Fractionated marine invertebrate extract libraries for drug discovery. Molecules 13:1372-83

Showing the most recent 10 out of 38 publications